Mechanisms, biology and inhibitors of deubiquitinating enzymes (Q36975731)

17 August 2017

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title

Mechanisms, biology and inhibitors of deubiquitinating enzymes (English)

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17 August 2017

4

Hidde L Ploegh

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17 August 2017

Kerry Routenberg Love

series ordinal

1

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17 August 2017

André Catic

series ordinal

2

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17 August 2017

Christian Schlieker

series ordinal

3

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17 August 2017

language of work or name

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1 November 2007

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17 August 2017

Nature Chemical Biology

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17 August 2017

3

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17 August 2017

697-705

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17 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nchembio.2007.43

17 August 2017

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cites work

Role of ubiquitin- and Ubl-binding proteins in cell signaling

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Modification of proteins by ubiquitin and ubiquitin-like proteins

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The ubiquitin signal: assembly, recognition and termination. Symposium on ubiquitin and signaling

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7 January 2021

Ubiquitin: structures, functions, mechanisms

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Evidence for a direct role of the Doa4 deubiquitinating enzyme in protein sorting into the MVB pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Deubiquitinating enzymes as novel anticancer targets

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

p53 ubiquitination: Mdm2 and beyond

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Defining biochemical functions for the BRCA1 tumor suppressor protein: analysis of the BRCA1 binding protein BAP1.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

A genomic and functional inventory of deubiquitinating enzymes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

ElaD, a Deubiquitinating protease expressed by E. coli

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Mechanism-based profiling of enzyme families

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Preferred in vivo ubiquitination sites.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

SseL, a Salmonella deubiquitinase required for macrophage killing and virulence.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Structural aspects of recently discovered viral deubiquitinating activities

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Bacterial interference of ubiquitination and deubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Illuminating the Evolutionary History of Chlamydiae

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Rickettsiae and Chlamydiae: evidence of horizontal gene transfer and gene exchange

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Solution structure of Urm1 and its implications for the origin of protein modifiers

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

From UBA to UBX: new words in the ubiquitin vocabulary.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The ubiquitin domain superfold: structure-based sequence alignments and characterization of binding epitopes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Ubiquitin--conserved protein or selfish gene?

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Sequence and structure evolved separately in a ribosomal ubiquitin variant

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Mechanism and function of deubiquitinating enzymes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Synthesis and characterization of ubiquitin ethyl ester, a new substrate for ubiquitin carboxyl-terminal hydrolase

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Kinetic studies of isopeptidase T: modulation of peptidase activity by ubiquitin

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Strategies for assaying deubiquitinating enzymes.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Substrate recognition and catalysis by UCH-L1

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Ubiquitin-binding domains

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

A substrate for deubiquitinating enzymes based on time-resolved fluorescence resonance energy transfer between terbium and yellow fluorescent protein.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Parkin and defective ubiquitination in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Ubiquitin and breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Identification of the familial cylindromatosis tumour-suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Drug discovery in the ubiquitin-proteasome system.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Auxiliary-mediated site-specific peptide ubiquitylation.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

A synthetic kiss of death: expressed protein ligation of a ubiquitin-peptide conjugate.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Ataxin-3 is subject to autolytic cleavage.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Protein modification by SUMO

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Identification and characterization of DEN1, a deneddylase of the ULP family

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.43

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.2007.43

1 reference

Dimensions Publication ID

17 August 2017

0 references

1 reference