Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions (Q36967654)

17 August 2017

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title

Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions (English)

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17 August 2017

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2

Xander H T Wehrens

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17 August 2017

Peter J Mohler

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17 August 2017

publication date

1 October 2007

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17 August 2017

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17 August 2017

volume

22

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17 August 2017

page(s)

342-350

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Prevalence of long-QT syndrome gene variants in sudden infant death syndrome

17 August 2017

cites work

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Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation

21 January 2018

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Localization of pacemaker channels in lipid rafts regulates channel kinetics

21 January 2018

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K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

21 January 2018

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Ankyrins and cellular targeting of diverse membrane proteins to physiological sites

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Evidence for cardiac sodium-calcium exchanger association with caveolin-3

21 January 2018

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Regulation of ryanodine receptors by FK506 binding proteins

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Subcellular distribution of ankyrin in developing rabbit heart--relationship to the Na+-Ca2+ exchanger

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Dual roles of the A kinase-anchoring protein Yotiao in the modulation of a cardiac potassium channel: a passive adaptor versus an active regulator

21 January 2018

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Novel mechanism for sudden infant death syndrome: persistent late sodium current secondary to mutations in caveolin-3

21 January 2018

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The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid rafts

21 January 2018

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Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B

21 January 2018

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Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments

21 January 2018

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mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

21 January 2018

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Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1)

21 January 2018

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Four potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in Finland

21 January 2018

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Calcium pump of the plasma membrane is localized in caveolae

21 January 2018

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Localization of inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae

21 January 2018

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Identification of Ank(G107), a muscle-specific ankyrin-G isoform.

21 January 2018

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Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities

21 January 2018

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Limb-girdle muscular dystrophy (LGMD-1C) mutants of caveolin-3 undergo ubiquitination and proteasomal degradation. Treatment with proteasomal inhibitors blocks the dominant negative effect of LGMD-1C mutanta and rescues wild-type caveolin-3.

21 January 2018

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A targeting motif involved in sodium channel clustering at the axonal initial segment.

21 January 2018

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Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes

21 January 2018

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Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction

21 January 2018

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Caveolin-3 deficiency causes muscle degeneration in mice

21 January 2018

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Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice

21 January 2018

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The KCNQ1 potassium channel: from gene to physiological function

21 January 2018

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Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death

21 January 2018

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RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)

21 January 2018

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Enhanced basal activity of a cardiac Ca2+ release channel (ryanodine receptor) mutant associated with ventricular tachycardia and sudden death

21 January 2018

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Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

21 January 2018

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AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier

21 January 2018

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Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel

21 January 2018

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Regulatory actions of the A-kinase anchoring protein Yotiao on a heart potassium channel downstream of PKA phosphorylation

21 January 2018

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Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia

21 January 2018

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Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

21 January 2018

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Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak

21 January 2018

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Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel α Subunits

21 January 2018

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Plasma Membrane-Cytoskeleton-Endoplasmic Reticulum Complexes in Neurons and Astrocytes

21 January 2018

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Signaling protein complexes associated with neuronal ion channels

21 January 2018

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Independent and exclusive modulation of cardiac delayed rectifying K+ current by protein kinase C and protein kinase A.

21 January 2018

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Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains.

21 January 2018

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Isoform-specific localization of voltage-gated K+ channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae

21 January 2018

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Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

21 January 2018

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Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers

21 January 2018

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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

21 January 2018

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Composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy.

21 January 2018

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Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Long QT syndrome: from channels to cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Goblin (ankyrin) in striated muscle: identification of the potential membrane receptor for erythroid spectrin in muscle cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Role of genetic analyses in cardiology: part I: mendelian diseases: cardiac channelopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Caveolae: from cell biology to animal physiology

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Long QT syndrome: reduced repolarization reserve and the genetic link

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Targeted mutational analysis of ankyrin-B in 541 consecutive, unrelated patients referred for long QT syndrome genetic testing and 200 healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

21 January 2018

Structure of caveolae

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

The role of molecular autopsy in unexplained sudden cardiac death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Modulation of Myoblast Fusion by Caveolin-3 in Dystrophic Skeletal Muscle Cells: Implications for Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy-1C

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Novel insights in the congenital long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Intracellular calcium release and cardiac disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

beta-Spectrin is colocalized with both voltage-gated sodium channels and ankyrinG at the adult rat neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Peptide probe study of the critical regulatory domain of the cardiac ryanodine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Localization of cardiac sodium channels in caveolin-rich membrane domains: regulation of sodium current amplitude

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Na+/Ca2+Exchange Facilitates Ca2+-dependent Activation of Endothelial Nitric-oxide Synthase

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00018.2007

10.1152/PHYSIOL.00018.2007

21 January 2018

Identifiers

DOI

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17 August 2017

1 reference