Extracellular control of TGFbeta signalling in vascular development and disease (Q36951674)

17 August 2017

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title

Extracellular control of TGFbeta signalling in vascular development and disease (English)

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17 August 2017

Helen M Arthur

2

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author name string

Peter ten Dijke

series ordinal

1

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17 August 2017

1 November 2007

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Nature Reviews Molecular Cell Biology

17 August 2017

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17 August 2017

8

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17 August 2017

857-869

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17 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrm2262

17 August 2017

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Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein

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Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability

31 March 2020

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Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

31 March 2020

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Fibrillin-1 regulates the bioavailability of TGFbeta1.

31 March 2020

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BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein

31 March 2020

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Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases

31 March 2020

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Thrombospondin-1 is a major activator of TGF-beta1 in vivo

31 March 2020

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Integrin-mediated activation of latent transforming growth factor beta

31 March 2020

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Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice

31 March 2020

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The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

31 March 2020

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31 March 2020

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Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

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31 March 2020

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31 March 2020

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Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

31 March 2020

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Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction

31 March 2020

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Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

31 March 2020

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Molecular regulation of angiogenesis and lymphangiogenesis

31 March 2020

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Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

31 March 2020

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Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis

31 March 2020

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Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling

31 March 2020

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MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration

31 March 2020

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VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis

31 March 2020

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

31 March 2020

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The TGF beta activated kinase TAK1 regulates vascular development in vivo

31 March 2020

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Gap junction communication mediates transforming growth factor-beta activation and endothelial-induced mural cell differentiation

31 March 2020

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Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia

31 March 2020

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Combinatorial Control of Smooth Muscle–Specific Gene Expression

31 March 2020

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Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development

31 March 2020

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Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development

31 March 2020

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Mutations of TGFbeta signaling molecules in human disease

31 March 2020

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Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

31 March 2020

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Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2.

31 March 2020

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Functional analysis of mutations in the kinase domain of the TGF-beta receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia

31 March 2020

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Endoglin expression in early development is associated with vasculogenesis and angiogenesis.

31 March 2020

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Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesions

31 March 2020

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Arteriovenous malformations in mice lacking activin receptor-like kinase-1

31 March 2020

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Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor

31 March 2020

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Reduced endothelial secretion and plasma levels of transforming growth factor-beta1 in patients with hereditary hemorrhagic telangiectasia type 1

31 March 2020

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BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

31 March 2020

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Generation of a floxed allele of the mouse Endoglin gene

31 March 2020

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Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

31 March 2020

1 reference

Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

31 March 2020

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Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells

31 March 2020

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Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

31 March 2020

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Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

31 March 2020

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Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia

31 March 2020

1 reference

Heterozygous TGFBR2 mutations in Marfan syndrome

31 March 2020

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A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2

31 March 2020

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Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections

31 March 2020

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Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-beta.

31 March 2020

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Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart

31 March 2020

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Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome

31 March 2020

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Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome

31 March 2020

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Fibrillins 1 and 2 perform partially overlapping functions during aortic development

31 March 2020

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Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome

31 March 2020

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Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice

31 March 2020

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Essential role of Smad3 in angiotensin II-induced vascular fibrosis

31 March 2020

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Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions

31 March 2020

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Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo

31 March 2020

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Fibulin-5/DANCE is essential for elastogenesis in vivo

31 March 2020

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Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice

31 March 2020

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Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice.

31 March 2020

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Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure. The Etude Cas-Témoin de l'Infarctus du Myocarde (ECTIM) Study

31 March 2020

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Emilin1 links TGF-beta maturation to blood pressure homeostasis

31 March 2020

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Transforming growth factor beta signaling, vascular remodeling, and hypertension

31 March 2020

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Soluble endoglin contributes to the pathogenesis of preeclampsia

31 March 2020

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Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1.

31 March 2020

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Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia

31 March 2020

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TGF-beta signaling in tumor suppression and cancer progression

31 March 2020

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TGF beta signaling in health and disease

31 March 2020

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Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.

31 March 2020

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Reduced angiogenic responses in adult Endoglin heterozygous mice

31 March 2020

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CD105 is important for angiogenesis: evidence and potential applications

31 March 2020

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Combination of low-dose cisplatin and recombinant xenogeneic endoglin as a vaccine induces synergistic antitumor activities.

31 March 2020

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Endoglin has a crucial role in blood cell-mediated vascular repair.

31 March 2020

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Cell signaling events: a view from the matrix

31 March 2020

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Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome

31 March 2020

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The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix

31 March 2020

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Regulation of limb patterning by extracellular microfibrils

31 March 2020

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Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice

31 March 2020

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Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states

31 March 2020

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Endothelial tubes assemble from intracellular vacuoles in vivo.

31 March 2020

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Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

31 March 2020

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Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia

31 March 2020

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Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

31 March 2020

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Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

31 March 2020

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A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2.

31 March 2020

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Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

31 March 2020

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BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia.

31 March 2020

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Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

31 March 2020

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A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4).

31 March 2020

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Aneurysm syndromes caused by mutations in the TGF-beta receptor

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2262

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17 August 2017

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PubMed ID

17895899