Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function (Q36950337)

17 August 2017

Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function (English)

1 reference

17 August 2017

chronic myeloid leukemia

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1 reference

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10

David A Rizzieri

1 reference

17 August 2017

Sharon Lim

1

1 reference

17 August 2017

Tzuen Yih Saw

2

1 reference

17 August 2017

Min Zhang

3

1 reference

17 August 2017

Matthew R Janes

4

1 reference

17 August 2017

Kassoum Nacro

5

1 reference

17 August 2017

Jeffrey Hill

6

1 reference

17 August 2017

An Qi Lim

7

1 reference

17 August 2017

Chia-Tien Chang

8

1 reference

17 August 2017

David A Fruman

9

1 reference

17 August 2017

Soo Yong Tan

11

1 reference

17 August 2017

Hung Fan

12

1 reference

17 August 2017

Charles T H Chuah

13

1 reference

17 August 2017

S Tiong Ong

14

1 reference

17 August 2017

language of work or name

English

0 references

publication date

4 June 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

17 August 2017

1 reference

17 August 2017

110

1 reference

17 August 2017

25

1 reference

17 August 2017

E2298-307

1 reference

describes a project that uses

17 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3690864/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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29 September 2017

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29 September 2017

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Mnk earmarks eIF4E for cancer therapy

29 September 2017

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Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development

29 September 2017

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eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

29 September 2017

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Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation

29 September 2017

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29 September 2017

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Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

29 September 2017

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Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance

29 September 2017

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The eIF4E RNA regulon promotes the Akt signaling pathway

29 September 2017

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Many roads lead to oncogene-induced senescence

29 September 2017

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A quantitative analysis of kinase inhibitor selectivity

29 September 2017

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Dissecting eIF4E action in tumorigenesis

29 September 2017

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The Biology of CML blast crisis

29 September 2017

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The selectivity of protein kinase inhibitors: a further update

29 September 2017

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Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors

29 September 2017

1 reference

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Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation

29 September 2017

1 reference

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Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation

29 September 2017

1 reference

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Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity

29 September 2017

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The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

29 September 2017

1 reference

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Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation

29 September 2017

1 reference

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Functional genomic analysis of the Wnt-wingless signaling pathway

29 September 2017

1 reference

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

29 September 2017

1 reference

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eIF4E--from translation to transformation

29 September 2017

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Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

29 September 2017

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Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis

29 September 2017

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

29 September 2017

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Eukaryotic translation initiation factors and regulators

29 September 2017

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Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

29 September 2017

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Phosphorylation and regulation of beta-catenin by casein kinase I epsilon

29 September 2017

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Prospective isolation of human clonogenic common myeloid progenitors

29 September 2017

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Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells

29 September 2017

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29 September 2017

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The molecular biology of chronic myeloid leukemia.

29 September 2017

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

29 September 2017

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The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways

29 September 2017

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A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation.

29 September 2017

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Targeting the BCR-ABL signaling pathway in therapy-resistant Philadelphia chromosome-positive leukemia

27 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

MNK, EIF4E and targeting translation for therapy.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690864

Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23737503

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23737503

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1301838110

1 reference

17 August 2017

0 references

1 reference

17 August 2017

1 reference