Identification of a new JNK inhibitor targeting the JNK-JIP interaction site (Q36938538)

17 August 2017

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site (English)

1 reference

17 August 2017

12

Michael Karin

1 reference

17 August 2017

John L Stebbins

1

1 reference

17 August 2017

Surya K De

2

1 reference

17 August 2017

Thomas Machleidt

3

1 reference

17 August 2017

Barbara Becattini

4

1 reference

17 August 2017

Jesus Vazquez

5

1 reference

17 August 2017

Christian Kuntzen

6

1 reference

17 August 2017

Li-Hsing Chen

7

1 reference

17 August 2017

Jason F Cellitti

8

1 reference

17 August 2017

Megan Riel-Mehan

9

1 reference

17 August 2017

Aras Emdadi

10

1 reference

17 August 2017

Giovanni Solinas

11

1 reference

17 August 2017

Maurizio Pellecchia

13

1 reference

17 August 2017

language of work or name

English

0 references

publication date

15 October 2008

1 reference

Proceedings of the National Academy of Sciences of the United States of America

17 August 2017

1 reference

17 August 2017

105

1 reference

17 August 2017

16809-16813

1 reference

17 August 2017

43

1 reference

Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

High-throughput cellular assays for regulated posttranslational modifications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Intracellular targeting of polymer-bound drugs for cancer chemotherapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

JNK: a new therapeutic target for diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Targeting JNK for therapeutic benefit: from junk to gold?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

A mammalian scaffold complex that selectively mediates MAP kinase activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

A cytoplasmic inhibitor of the JNK signal transduction pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Development and validation of a genetic algorithm for flexible docking

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Selective interaction of JNK protein kinase isoforms with transcription factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Developmental expression in the mouse nervous system of the p493F12 SAP kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Identification of the critical features of a small peptide inhibitor of JNK activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Regulation and function of the JNK subgroup of MAP kinases

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Development of paramagnetic probes for molecular recognition studies in protein kinases

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567907

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18922779

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18922779

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Texture mapping: a new tool for molecular graphics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18922779

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0805677105

1 reference

17 August 2017

0 references

1 reference

17 August 2017

1 reference