Preclinical evaluation of the abuse potential of Pitolisant, a histamine H₃ receptor inverse agonist/antagonist compared with Modafinil (Q36929453)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23472741%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

Preclinical evaluation of the abuse potential of Pitolisant, a histamine H₃ receptor inverse agonist/antagonist compared with Modafinil (English)

1 reference

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25 February 2020

1 reference

4

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25 February 2020

author name string

M Uguen

1

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25 February 2020

D Perrin

2

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25 February 2020

S Belliard

3

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25 February 2020

P M Beardsley

5

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25 February 2020

J M Lecomte

6

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25 February 2020

J C Schwartz

7

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25 February 2020

language of work or name

English

0 references

publication date

1 June 2013

1 reference

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British Journal of Pharmacology

25 February 2020

published in

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25 February 2020

volume

169

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25 February 2020

issue

3

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25 February 2020

page(s)

632-644

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Interactions between modafinil and cocaine during the induction of conditioned place preference and locomotor sensitization in mice: implications for addiction

25 February 2020

cites work

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R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse

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Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?

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Chronic modafinil effects on drug-seeking following methamphetamine self-administration in rats.

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Evidence for the role of histamine H3 receptor in alcohol consumption and alcohol reward in mice

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The histamine H3 receptor: from discovery to clinical trials with pitolisant

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Histamine H3 receptors and sleep-wake regulation

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Modafinil blocks reinstatement of extinguished opiate-seeking in rats: mediation by a glutamate mechanism

29 September 2017

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Dopamine transporter-related effects of modafinil in rhesus monkeys

29 September 2017

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Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse

29 September 2017

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Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents

29 September 2017

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Modafinil reinstates a cocaine conditioned place preference following extinction in rats

29 September 2017

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Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications

29 September 2017

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Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil

29 September 2017

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An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients

29 September 2017

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Modafinil evokes striatal [(3)H]dopamine release and alters the subjective properties of stimulants

29 September 2017

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Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.

29 September 2017

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GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models

29 September 2017

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BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology

29 September 2017

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29 September 2017

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29 September 2017

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Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats

29 September 2017

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29 September 2017

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A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain

29 September 2017

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High constitutive activity of native H3 receptors regulates histamine neurons in brain.

29 September 2017

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Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington's and Parkinson's disease cases

29 September 2017

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The self-administration of MK-801 can depend upon drug-reinforcement history, and its discriminative stimulus properties are phencyclidine-like in rhesus monkeys

29 September 2017

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Histaminergic transmission in the mammalian brain

29 September 2017

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The H3 antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice

29 September 2017

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Evaluation of the cocaine-like discriminative stimulus effects and reinforcing effects of modafinil

27 June 2018

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Thioperamide, the selective histamine H3 receptor antagonist, attenuates stimulant-induced locomotor activity in the mouse

27 June 2018

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Development and maintenance of morphine tolerance and dependence in the rat by scheduled access to morphine drinking solutions

27 June 2018

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Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study.

27 June 2018

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JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.

4 September 2018

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Effects of histamine H3 receptor ligands on the rewarding, stimulant and motor-impairing effects of ethanol in DBA/2J mice.

4 September 2018

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Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

4 September 2018

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Methamphetamine- and 3,4-methylenedioxymethamphetamine-induced behavioral changes in histamine H3-receptor knockout mice

4 September 2018

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The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward.

4 September 2018

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Dopamine D3 receptor ligands block nicotine-induced conditioned place preferences through a mechanism that does not involve discriminative-stimulus or antidepressant-like effects

4 September 2018

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Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoam

4 September 2018

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Histamine h3 receptor antagonists potentiate methamphetamine self-administration and methamphetamine-induced accumbal dopamine release

4 September 2018

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H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization

4 September 2018

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Modulation of the discriminative stimulus effects of cocaine and methamphetamine by the histaminergic system.

4 September 2018

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Study of the addictive potential of modafinil in naive and cocaine-experienced rats

4 September 2018

1 reference

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Potentiation of the discriminative-stimulus effects of methamphetamine by the histamine H3 receptor antagonist thioperamide in rats.

4 September 2018

1 reference

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Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues

4 September 2018

1 reference

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The vigilance promoting drug modafinil increases dopamine release in the rat nucleus accumbens via the involvement of a local GABAergic mechanism.

4 September 2018

1 reference

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A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682710

Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23472741

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Analysis of stimulant locomotor effects of modafinil in various strains of mice and rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23472741

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/BPH.12149

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23472741%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23472741%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23472741%20AND%20SRC:MED&resulttype=core&format=json