LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence (Q36929071)

17 August 2017

LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence (English)

1 reference

17 August 2017

Erik R Kline

1

1 reference

17 August 2017

John Shupe

2

1 reference

17 August 2017

Melissa Gilbert-Ross

3

1 reference

17 August 2017

Wei Zhou

4

1 reference

17 August 2017

Adam I Marcus

5

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 May 2013

1 reference

Journal of Biological Chemistry

17 August 2017

1 reference

17 August 2017

288

1 reference

17 August 2017

24

1 reference

17 August 2017

17663-17674

1 reference

describes a project that uses

17 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3682567/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain

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Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues

29 September 2017

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Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation

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LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity

29 September 2017

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Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

29 September 2017

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Src activation and translocation from focal adhesions to membrane ruffles contribute to formation of new adhesion sites

29 September 2017

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Polarity proteins in migration and invasion

29 September 2017

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Somatic mutations affect key pathways in lung adenocarcinoma

29 September 2017

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Crosstalk between small GTPases and polarity proteins in cell polarization.

29 September 2017

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Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation

29 September 2017

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Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways

29 September 2017

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The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity

29 September 2017

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29 September 2017

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AMPK/LKB1 signaling in epithelial cell polarity and cell division

29 September 2017

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LKB1 modulates lung cancer differentiation and metastasis

29 September 2017

1 reference

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LKB1 and AMPK maintain epithelial cell polarity under energetic stress

29 September 2017

1 reference

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Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function

29 September 2017

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CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins

29 September 2017

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Molecular requirements for epithelial-mesenchymal transition during tumor progression

29 September 2017

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Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

29 September 2017

1 reference

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The LKB1 tumor suppressor negatively regulates mTOR signaling

29 September 2017

1 reference

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Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene

29 September 2017

1 reference

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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

29 September 2017

1 reference

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FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

29 September 2017

1 reference

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Epithelial-mesenchymal transitions in development and pathologies

29 September 2017

1 reference

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Epithelial-mesenchymal transitions in tumour progression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Focal adhesion kinase is involved in mechanosensing during fibroblast migration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Multiple paxillin binding sites regulate FAK function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Focal adhesion kinase: important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682567

Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.444620

A Novel Gene Expression Profile in Lymphatics Associated with Tumor Growth and Nodal Metastasis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.444620

Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23637231

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.444620

1 reference

17 August 2017

1 reference

17 August 2017

1 reference