Role of telomeres and telomerase in genomic instability, senescence and cancer (Q36927502)

17 August 2017

1 reference

title

Role of telomeres and telomerase in genomic instability, senescence and cancer (English)

1 reference

17 August 2017

Yibin Deng

1

1 reference

PubMed ID

17767195

17 August 2017

Sandy Chang

series ordinal

2

1 reference

17 August 2017

3 September 2007

1 reference

17 August 2017

Laboratory Investigation

1 reference

17 August 2017

87

1 reference

17 August 2017

11

1 reference

17 August 2017

1071-1076

1 reference

https://scigraph.springernature.com/pub.10.1038/labinvest.3700673

17 August 2017

0 references

cites work

The age distribution of cancer and a multi-stage theory of carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Genetic instabilities in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Mutations of mitotic checkpoint genes in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Analysis of p53 mutations in cells taken from paraffin-embedded tissue sections of ductal carcinoma in situ and atypical ductal hyperplasia of the breast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Shelterin: the protein complex that shapes and safeguards human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomeres shorten during ageing of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomere length predicts replicative capacity of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Senescence, apoptosis and therapy--cutting the lifelines of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Short telomeres limit tumor progression in vivo by inducing senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Reversal of human cellular senescence: roles of the p53 and p16 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

p53 gene status and expression of p53, mdm2, and p21Waf1/Cip1 proteins in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomere dysfunction provokes regional amplification and deletion in cancer genomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

In situ analyses of genome instability in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomere shortening occurs early during breast tumorigenesis: a cause of chromosome destabilization underlying malignant transformation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomerase therapeutics for cancer: challenges and new directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomerase-based immunotherapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Antitumor effects of specific telomerase inhibitor GRN163 in human glioblastoma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

7 January 2021

Telomeres limit cancer growth by inducing senescence: long-sought in vivo evidence obtained

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

7 January 2021

Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

7 January 2021

In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

7 January 2021

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700673

7 January 2021

10.1038/LABINVEST.3700673

Identifiers

DOI

1 reference

PubMed ID

17767195

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

17767195