Keap1 eye on the target: chemoprevention of liver cancer (Q36920757)

17 August 2017

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title

Keap1 eye on the target: chemoprevention of liver cancer (English)

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17 August 2017

Melinda Sue Yates

1

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PubMed ID

17723167

17 August 2017

Thomas Wells Kensler

series ordinal

2

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17 August 2017

1 September 2007

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Acta Pharmacologica Sinica

17 August 2017

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17 August 2017

28

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17 August 2017

9

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17 August 2017

1331-1342

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https://scigraph.springernature.com/pub.10.1111/j.1745-7254.2007.00688.x

17 August 2017

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Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group

21 January 2018

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21 January 2018

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Mutagenic activation of aflatoxin B1 by several forms of purified cytochrome P-450.

21 January 2018

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2007.00688.X

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2007.00688.X

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

21 January 2018

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Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust

21 January 2018

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Role of phase 2 enzyme induction in chemoprotection by dithiolethiones

21 January 2018

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Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

21 January 2018

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An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site

21 January 2018

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Chemical and molecular regulation of enzymes that detoxify carcinogens

21 January 2018

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Axis determination by inhibition of Wnt signaling in Xenopus

21 January 2018

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

21 January 2018

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

21 January 2018

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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

21 January 2018

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Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.

21 January 2018

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The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

21 January 2018

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Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones

21 January 2018

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Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis

21 January 2018

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Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice

21 January 2018

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Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

21 January 2018

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The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

21 January 2018

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Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages

21 January 2018

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Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

21 January 2018

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Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

21 January 2018

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Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

21 January 2018

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Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2007.00688.X

Compressing drug development timelines in oncology using phase '0' trials.

21 January 2018

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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2007.00688.X

10.1111/J.1745-7254.2007.00688.X

21 January 2018

Identifiers

DOI

1 reference

PubMed ID

17723167

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

17723167