Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. (Q36920140)

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11 January 2020

title

Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase (English)

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11 January 2020

1

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11 January 2020

author name string

Inkyu Hwang

2

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11 January 2020

Stephen Connelly

3

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11 January 2020

Ian A Wilson

4

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11 January 2020

Dale L Boger

5

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language of work or name

English

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publication date

8 August 2008

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Journal of Medicinal Chemistry

11 January 2020

published in

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11 January 2020

volume

51

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11 January 2020

issue

17

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11 January 2020

page(s)

5441-5448

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Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway

11 January 2020

cites work

1 reference

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Deaza Analogs of Folic Acid as Antitumor Agents

29 September 2017

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Biosynthesis of the purines. XIX. 2-Amino-N-ribosylacetamide 5'-phosphate (glycinamide ribotide) transformylase.

29 September 2017

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Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid

29 September 2017

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New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid

29 September 2017

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Clinical pharmacokinetics of antitumor antifolates

29 September 2017

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AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase

29 September 2017

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Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol

29 September 2017

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Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

29 September 2017

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N10-Formyltetrahydrofolate is the formyl donor for glycinamide ribotide transformylase in Escherichia coli

29 September 2017

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Antifolates in clinical development.

29 September 2017

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Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents

27 June 2018

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10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

27 June 2018

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Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway

4 September 2018

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12 December 2020

Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method

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12 December 2020

A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors

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12 December 2020

Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis

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12 December 2020

Identifiers

DOI

10.1021/JM800555H

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11 January 2020

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11 January 2020

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