Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics (Q36918125)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26873728%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26873728%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

14

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7 March 2020

Melissa Fishel

21

1 reference

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7 March 2020

author name string

Carolyn C Arpin

1

1 reference

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7 March 2020

Stephen Mac

2

1 reference

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7 March 2020

Yanlin Jiang

3

1 reference

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7 March 2020

Huiwen Cheng

4

1 reference

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7 March 2020

Michelle Grimard

5

1 reference

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7 March 2020

Brent D G Page

6

1 reference

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7 March 2020

Malgorzata M Kamocka

7

1 reference

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7 March 2020

Sina Haftchenary

8

1 reference

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7 March 2020

Han Su

9

1 reference

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7 March 2020

Daniel P Ball

10

1 reference

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7 March 2020

David A Rosa

11

1 reference

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7 March 2020

Ping-Shan Lai

12

1 reference

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7 March 2020

Rodolfo F Gómez-Biagi

13

1 reference

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7 March 2020

Rahul Rana

15

1 reference

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7 March 2020

Helmut Hanenberg

16

1 reference

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7 March 2020

Kagan Kerman

17

1 reference

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7 March 2020

Kyle C McElyea

18

1 reference

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7 March 2020

George E Sandusky

19

1 reference

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7 March 2020

Patrick T Gunning

20

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7 March 2020

language of work or name

English

0 references

publication date

12 February 2016

1 reference

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Molecular Cancer Therapeutics

7 March 2020

published in

1 reference

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7 March 2020

volume

15

1 reference

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7 March 2020

issue

5

1 reference

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7 March 2020

page(s)

794-805

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Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.

7 March 2020

cites work

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STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer cells

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3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

29 September 2017

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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

29 September 2017

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APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival

29 September 2017

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First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.

29 September 2017

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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

29 September 2017

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STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice

29 September 2017

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Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

29 September 2017

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A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells

29 September 2017

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STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

29 September 2017

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29 September 2017

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Pancreatic cancer associated fibroblasts display normal allelotypes.

29 September 2017

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Modeling tissue morphogenesis and cancer in 3D.

29 September 2017

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

29 September 2017

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Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

29 September 2017

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Transcriptional anti-angiogenesis therapy of human pancreatic cancer

29 September 2017

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A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

29 September 2017

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Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells

29 September 2017

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Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells

29 September 2017

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29 September 2017

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29 September 2017

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The STATs of cancer--new molecular targets come of age

29 September 2017

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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

29 September 2017

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A road map for those who don't know JAK-STAT

29 September 2017

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STATs and gene regulation

29 September 2017

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Tesaglitazar, a dual PPAR-α/γ agonist, hamster carcinogenicity, investigative animal and clinical studies

29 September 2017

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Two mitosis-specific antibodies, MPM-2 and phospho-histone H3 (Ser28), allow rapid and precise determination of mitotic activity.

27 June 2018

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Modulation of gene expression and tumor cell growth by redox modification of STAT3.

27 June 2018

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Inhibition of Stat3 by cell-permeable peptidomimetic prodrugs targeted to its SH2 domain.

4 September 2018

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In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

4 September 2018

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Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

4 September 2018

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Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26873728

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26873728

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1535-7163.MCT-15-0003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26873728%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

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7 March 2020

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