Optimizing drug exposure to minimize selection of antibiotic resistance (Q36903693)

17 August 2017

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title

Optimizing drug exposure to minimize selection of antibiotic resistance (English)

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17 August 2017

antibiotic resistance

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Sara K Olofsson

1

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PubMed ID

17683017

17 August 2017

Otto Cars

series ordinal

2

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PubMed ID

17683017

17 August 2017

language of work or name

English

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publication date

1 September 2007

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Clinical Infectious Diseases

17 August 2017

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17 August 2017

45 Suppl 2

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17 August 2017

S129-36

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Antibiotic therapy of community respiratory tract infections: strategies for optimal outcomes and minimized resistance emergence

17 August 2017

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Optimising dosing strategies of antibacterials utilising pharmacodynamic principles: impact on the development of resistance

21 January 2018

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Muller's ratchet decreases fitness of a DNA-based microbe

21 January 2018

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Hypermutable bacteria isolated from humans--a critical analysis

21 January 2018

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Spontaneous mutators in bacteria: insights into pathways of mutagenesis and repair

21 January 2018

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An elevated mutation frequency favors development of vancomycin resistance in Staphylococcus aureus

21 January 2018

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Mutator bacteria as a risk factor in treatment of infectious diseases

21 January 2018

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Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.

21 January 2018

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Bacteria with increased mutation frequency and antibiotic resistance are enriched in the commensal flora of patients with high antibiotic usage.

21 January 2018

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Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

21 January 2018

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The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants.

21 January 2018

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Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

21 January 2018

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The biological cost of antibiotic resistance

21 January 2018

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Biological costs and mechanisms of fosfomycin resistance in Escherichia coli

21 January 2018

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Fitness of antibiotic resistant Staphylococcus epidermidis assessed by competition on the skin of human volunteers

21 January 2018

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Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.

21 January 2018

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Fitness cost of chromosomal drug resistance-conferring mutations

21 January 2018

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Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori

21 January 2018

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Persistence of resistant Staphylococcus epidermidis after single course of clarithromycin

21 January 2018

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Virulence of antibiotic-resistant Salmonella typhimurium

21 January 2018

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Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance

21 January 2018

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Dose ranging and fractionation of intravenous ciprofloxacin against Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro model of infection

21 January 2018

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Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis

21 January 2018

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Comparative study of the effects of ceftizoxime, piperacillin, and piperacillin-tazobactam concentrations on antibacterial activity and selection of antibiotic-resistant mutants of Enterobacter cloacae and Bacteroides fragilis in vitro and in vivo i

21 January 2018

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The effects of oral and intramuscular administration and dose escalation of enrofloxacin on the selection of quinolone resistance among Salmonella and coliforms in pigs

21 January 2018

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Low dosage and long treatment duration of beta-lactam: risk factors for carriage of penicillin-resistant Streptococcus pneumoniae.

21 January 2018

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Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia

21 January 2018

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Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'.

21 January 2018

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Concentration-dependent selection of small phenotypic differences in TEM beta-lactamase-mediated antibiotic resistance

21 January 2018

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Ecological disturbances in intestinal microflora caused by clinafloxacin, an extended-spectrum quinolone.

21 January 2018

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Microdialysis for in vivo pharmacokinetic/pharmacodynamic characterization of anti-infective drugs

21 January 2018

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Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update

21 January 2018

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Emergence of resistant Streptococcus pneumoniae in an in vitro dynamic model that simulates moxifloxacin concentrations inside and outside the mutant selection window: related changes in susceptibility, resistance frequency and bacterial killing

21 January 2018

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In vitro activities of mutant prevention concentration-targeted concentrations of fluoroquinolones against Staphylococcus aureus in a pharmacodynamic model

21 January 2018

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Activities of moxifloxacin against, and emergence of resistance in, Streptococcus pneumoniae and Pseudomonas aeruginosa in an in vitro pharmacokinetic model

21 January 2018

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Pharmacodynamic model to describe the concentration-dependent selection of cefotaxime-resistant Escherichia coli

21 January 2018

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Suboptimal antibiotic dosage as a risk factor for selection of penicillin-resistant Streptococcus pneumoniae: in vitro kinetic model

21 January 2018

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In vitro selective antibiotic concentrations of beta-lactams for penicillin-resistant Streptococcus pneumoniae populations

21 January 2018

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Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies

21 January 2018

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Mutant selection window hypothesis updated.

21 January 2018

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Antimicrobial drug use and resistance among respiratory pathogens in the community

21 January 2018

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Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli

21 January 2018

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Low correlation between MIC and mutant prevention concentration

21 January 2018

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Mutant prevention concentrations for single-step fluoroquinolone-resistant mutants of wild-type, efflux-positive, or ParC or GyrA mutation-containing Streptococcus pneumoniae isolates

21 January 2018

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Stretching the mutant prevention concentration (MPC) beyond its limits

21 January 2018

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The mutant selection window and antimicrobial resistance

21 January 2018

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Mutant prevention concentrations of fluoroquinolones for clinical isolates of Streptococcus pneumoniae.

21 January 2018

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Activities of mutant prevention concentration-targeted moxifloxacin and levofloxacin against Streptococcus pneumoniae in an in vitro pharmacodynamic model

21 January 2018

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In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus.

21 January 2018

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The mutant selection window in rabbits infected with Staphylococcus aureus.

21 January 2018

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Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration.

21 January 2018

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Mutant prevention concentration as a measure of antibiotic potency: studies with clinical isolates of Mycobacterium tuberculosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1086/519256

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17 August 2017

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PubMed ID

17683017