Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins (Q36898672)

17 August 2017

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title

Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins (English)

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17 August 2017

3

Luke A J O'Neill

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17 August 2017

Tanya M Watters

1

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PubMed ID

17667936

17 August 2017

Elaine F Kenny

series ordinal

2

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17 August 2017

31 July 2007

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Immunology & Cell Biology

17 August 2017

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17 August 2017

85

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17 August 2017

411-419

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17 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/sj.icb.7100095

17 August 2017

0 references

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Approaching the asymptote? Evolution and revolution in immunology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Inferences, questions and possibilities in Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Recognition and signaling by toll-like receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Pathogen recognition and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Toll-like receptor control of the adaptive immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Negative regulation of toll-like receptor-mediated immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Inherited disorders of human Toll-like receptor signaling: immunological implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The molecular structure of the Toll-like receptor 3 ligand-binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The dsRNA binding site of human Toll-like receptor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The role of Toll-like receptor 2 in microbial disease and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Opposing effects of Toll-like receptor stimulation induce autoimmunity or tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Leucine-rich repeats and pathogen recognition in Toll-like receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

CD14 is required for MyD88-independent LPS signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

CD36 is a sensor of diacylglycerides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Toll-like receptors as molecular switches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

MyD88, an adapter protein involved in interleukin-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Structure and function of Toll receptors and their ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

21 January 2018

Signaling to NF-kappaB

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

TIRAP: an adapter molecule in the Toll signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Regulation of signal transduction and signal diversity by receptor oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

A family of human receptors structurally related to Drosophila Toll

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The smallest known non-avian theropod dinosaur

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Binding specificity of Toll-like receptor cytoplasmic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Sorting out Toll signals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Genetically Resistant Mice Lacking MyD88-Adapter Protein Display a High Susceptibility to Leishmania major Infection Associated with a Polarized Th2 Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

Unresponsiveness of MyD88-deficient mice to endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

inferred from DOI database lookup

7 January 2021

based on heuristic

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100095

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ICB.7100095

1 reference

PubMed ID

17667936

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

17667936