Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity (Q36876799)

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scientific article published on 18 October 2007

Language	Label	Description	Also known as
English	Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity	scientific article published on 18 October 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Christopher J. Moody

object named as

Christopher J Moody

6

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author name string

Marie A Colucci

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Philip Reigan

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

David Siegel

3

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Aurélie Chilloux

4

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Europe PubMed Central

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16 August 2017

David Ross

5

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Europe PubMed Central

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16 August 2017

language of work or name

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publication date

18 October 2007

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Europe PubMed Central

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16 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

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16 August 2017

50

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Europe PubMed Central

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16 August 2017

23

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

5780-5789

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

Quinone reductases multitasking in the metabolic world

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

Mechanisms of action of quinone-containing alkylating agents. I: NQO1-directed drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

Enzymology of bioreductive drug activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

29 September 2017

Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

27 June 2018

The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

4 September 2018

NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

4 September 2018

Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

4 September 2018

Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

4 September 2018

Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536657

4 September 2018

5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17944451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17944451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17944451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclopropamitosenes, Novel Bioreductive Anticancer Agents. Synthesis, Electrochemistry, and Biological Activity of 7-Substituted Cyclopropamitosenes and Related Indolequinones

1 reference

https://pubmed.ncbi.nlm.nih.gov/17944451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM070396Q

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

ResearchGate publication ID

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