The synthesis of highly substituted isoxazoles by electrophilic cyclization: an efficient synthesis of valdecoxib (Q36862899)

16 August 2017

The synthesis of highly substituted isoxazoles by electrophilic cyclization: an efficient synthesis of valdecoxib (English)

1 reference

16 August 2017

Jesse P Waldo

1

1 reference

PMCID

2529460

16 August 2017

Richard C Larock

series ordinal

2

1 reference

PMCID

2529460

16 August 2017

language of work or name

English

0 references

publication date

3 November 2007

1 reference

Journal of Organic Chemistry

16 August 2017

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16 August 2017

72

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16 August 2017

25

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16 August 2017

9643-9647

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Synthesis of 3,4-disubstituted 2H-benzopyrans through C-C bond formation via electrophilic cyclization

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

Syntheses of isochromenes and naphthalenes by electrophilic cyclization of acetylenic arenecarboxaldehydes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

Synthesis of 2,3-disubstituted benzo[b]selenophenes via electrophilic cyclization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

Synthesis of naphthalenes and 2-naphthols by the electrophilic cyclization of alkynes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

Synthesis of 3-iodoindoles by the Pd/Cu-catalyzed coupling of N,N-dialkyl-2-iodoanilines and terminal acetylenes, followed by electrophilic cyclization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

Synthesis of 2,3-disubstituted benzo[b]furans by the palladium-catalyzed coupling of o-iodoanisoles and terminal alkynes, followed by electrophilic cyclization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

Palladium-catalyzed cross-coupling reactions in total synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

IPy2BF4-promoted intramolecular addition of masked and unmasked anilines to alkynes: direct assembly of 3-iodoindole cores

29 September 2017

1 reference

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Selective inhibitors of cyclooxygenase-2 (COX-2).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors

29 September 2017

1 reference

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Regio- and stereoselective synthesis of isoindolin-1-ones via electrophilic cyclization

27 June 2018

1 reference

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Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity

4 September 2018

1 reference

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Synthesis and Biological Evaluation of N-Heterocyclic Indolyl Glyoxylamides as Orally Active Anticancer Agents

4 September 2018

1 reference

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[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents.

4 September 2018

1 reference

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Synthesis of fluoren-9-ones by the palladium-catalyzed cyclocarbonylation of o-halobiaryls

4 September 2018

1 reference

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Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling

4 September 2018

1 reference

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Synthesis of 2,3-disubstituted benzo[b]thiophenes via palladium-catalyzed coupling and electrophilic cyclization of terminal acetylenes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2529460

Synthesis of substituted isoquinolines by electrophilic cyclization of iminoalkynes

4 September 2018

1 reference

12 December 2020

Efficient syntheses of heterocycles and carbocycles by electrophilic cyclization of acetylenic aldehydes and ketones

1 reference

12 December 2020

Cyclization of carbonyl groups onto alkynes upon reaction with IPy2BF4 and their trapping with nucleophiles: a versatile trigger for assembling oxygen heterocycles

1 reference

12 December 2020

A novel palladium-mediated coupling approach to 2,3-disubstituted benzo(b)thiophenes and its application to the synthesis of tubulin binding agents

1 reference

12 December 2020

Synthesis of 3-iodoindoles by electrophilic cyclization of N,N-dialkyl-2-(1-alkynyl)anilines

1 reference

12 December 2020

Synthesis of isocoumarins and alpha-pyrones via electrophilic cyclization

1 reference

12 December 2020

Carbonylative Sonogashira coupling of terminal alkynes with aqueous ammonia

1 reference

12 December 2020

Electrophilic cyclization of o-acetoxy- and o-benzyloxyalkynylpyridines: an easy entry into 2,3-disubstituted furopyridines

1 reference

12 December 2020

Synthesis of isoquinolines and naphthyridines by electrophilic ring closure of iminoalkynes

1 reference

12 December 2020

Synthesis of fluoren-9-ones via palladium-catalyzed cyclocarbonylation of o-halobiaryls

1 reference

12 December 2020

Diversity-oriented synthesis of 3-iodochromones and heteroatom analogues via ICl-induced cyclization

1 reference

12 December 2020

Synthesis and pharmacological activities of novel 3-(isoxazol-3-yl)-quinazolin-4(3H)-one derivatives

1 reference

12 December 2020

5-Endo-dig electrophilic cyclization of 1,4-disubstituted but-3-yn-1-ones: regiocontrolled synthesis of 2,5-disubstituted 3-bromo- and 3-iodofurans

1 reference

12 December 2020

Synthesis of isoxazoles via electrophilic cyclization

1 reference

12 December 2020

AuCl(3)-catalyzed synthesis of highly substituted furans from 2-(1-alkynyl)-2-alken-1-ones

1 reference

12 December 2020

The geometry of displacements at nonstereogenic atoms: the formal displacement of alkoxide from alkoxyamines by organolithium reagents

1 reference

12 December 2020

Synthesis of highly substituted furans by the electrophile-induced coupling of 2-(1-alkynyl)-2-alken-1-ones and nucleophiles

1 reference

12 December 2020

Identifiers

DOI

10.1021/JO701942E

1 reference

16 August 2017

1 reference

16 August 2017

1 reference

PMCID

2529460