Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine. (Q36844320)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16388603%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine (English)

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15 January 2020

1

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15 January 2020

author name string

John M Denu

series ordinal

2

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15 January 2020

language of work or name

English

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publication date

1 January 2006

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15 January 2020

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15 January 2020

volume

45

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15 January 2020

issue

1

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15 January 2020

page(s)

272-282

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The Sir 2 family of protein deacetylases

15 January 2020

cites work

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Splicing regulates NAD metabolite binding to histone macroH2A.

29 September 2017

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Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

29 September 2017

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Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

29 September 2017

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SIRT1 regulates HIV transcription via Tat deacetylation

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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

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29 September 2017

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Mammalian SIRT1 represses forkhead transcription factors

29 September 2017

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

29 September 2017

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Quantitative assays for characterization of the Sir2 family of NAD(+)-dependent deacetylases

29 September 2017

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Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2′-O-Acetyl ADP Ribose and Histone Peptide

29 September 2017

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A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei

29 September 2017

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Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle

29 September 2017

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The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae

29 September 2017

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

29 September 2017

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Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases

29 September 2017

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Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

29 September 2017

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SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

29 September 2017

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Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases

29 September 2017

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Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

29 September 2017

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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

29 September 2017

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Structural basis for the NAD-dependent deacetylase mechanism of Sir2

29 September 2017

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

29 September 2017

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Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases

29 September 2017

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Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

29 September 2017

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The molecular biology of the SIR proteins

29 September 2017

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

29 September 2017

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Negative control of p53 by Sir2alpha promotes cell survival under stress

29 September 2017

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Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2

29 September 2017

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Crystal structure of a SIR2 homolog-NAD complex

29 September 2017

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

29 September 2017

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The human histone deacetylase family

29 September 2017

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Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product

29 September 2017

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Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

29 September 2017

1 reference

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

29 September 2017

1 reference

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A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

29 September 2017

1 reference

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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

29 September 2017

1 reference

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

29 September 2017

1 reference

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An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519119

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519119

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

29 September 2017

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

29 September 2017

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The stereospecificity of pig brain NAD-glycohydrolase-catalyzed methanolysis of NAD+

29 September 2017

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Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD(+) glycohydrolases

29 September 2017

1 reference

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Human CD38 is an authentic NAD(P)+ glycohydrolase

27 June 2018

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Investigation of diffusion-limited rates of chymotrypsin reactions by viscosity variation

27 June 2018

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Adenosine deaminase: viscosity studies and the mechanism of binding of substrate and of ground- and transition-state analogue inhibitors.

27 June 2018

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The stereochemistry of calf spleen NAD‐glycohydrolase‐catalyzed NAD methanolysis

27 June 2018

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Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation

27 June 2018

1 reference

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Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519119

Structural basis for the mechanism and regulation of Sir2 enzymes.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519119

Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519119

Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519119

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519119

Diffusion-limited component of reactions catalyzed by Bacillus cereus beta-lactamase I.

5 September 2018

1 reference

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Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2519119

Adenosine diphosphoribose transfer reactions catalyzed by Bungarus fasciatus venom NAD glycohydrolase

5 September 2018

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12 December 2020

Mechanism of cyclization of pyridine nucleotides by bovine spleen NAD+ glycohydrolase

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12 December 2020

The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries

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12 December 2020

Role of NAD(+) in the deacetylase activity of the SIR2-like proteins

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12 December 2020

Identifiers

DOI

10.1021/BI052014T

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16388603%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16388603%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference