Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis (Q36836804)

16 August 2017

1 reference

title

Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis (English)

1 reference

16 August 2017

Alan C Rapraeger

1

1 reference

PMCID

3651771

16 August 2017

language of work or name

English

0 references

publication date

24 February 2013

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16 August 2017

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16 August 2017

280

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16 August 2017

10

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16 August 2017

2207-2215

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Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenes

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

The role of β3-integrins in tumor angiogenesis: context is everything

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Proteoglycans in health and disease: the multiple roles of syndecan shedding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis

29 September 2017

1 reference

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Biochemical and structural properties of the integrin-associated cytoskeletal protein talin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Integrin signalling at a glance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

29 September 2017

1 reference

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Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer

29 September 2017

1 reference

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The role of adherens junctions and VE-cadherin in the control of vascular permeability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Integrins in angiogenesis and lymphangiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways.

29 September 2017

1 reference

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Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis

29 September 2017

1 reference

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Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling

29 September 2017

1 reference

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Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism

29 September 2017

1 reference

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A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

29 September 2017

1 reference

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Apoptotic cues from the extracellular matrix: regulators of angiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Role of angiogenesis in tumor growth and metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Syndecans and cell adhesion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Inhibition of angiogenesis and tumor growth by SCH221153, a dual alpha(v)beta3 and alpha(v)beta5 integrin receptor antagonist.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Angiogenesis in cancer and other diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Bone resorption by osteoclasts

29 September 2017

1 reference

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Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain

29 September 2017

1 reference

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Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3.

29 September 2017

1 reference

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Distinct antitumor properties of a type IV collagen domain derived from basement membrane

29 September 2017

1 reference

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Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

29 September 2017

1 reference

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The role of integrins in the malignant phenotype of gliomas

29 September 2017

1 reference

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Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin

29 September 2017

1 reference

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alphavbeta3 integrin mediates the cell-adhesive capacity and biological activity of basic fibroblast growth factor (FGF-2) in cultured endothelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Identification of an adhesion site within the syndecan-4 extracellular protein domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Stage-specific expression of integrin alphaVbeta3 in neuroblastic tumors.

29 September 2017

1 reference

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Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Requirement of vascular integrin alpha v beta 3 for angiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

alpha(v)beta(3) integrin engagement modulates cell adhesion, proliferation, and protease secretion in human lymphoid tumor cells.

27 June 2018

1 reference

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Role of the beta3 integrin subunit in human primary melanoma progression: multifunctional activities associated with alpha(v)beta3 integrin expression

27 June 2018

1 reference

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Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease

27 June 2018

1 reference

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27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651771

Syndecan-1-mediated cell spreading requires signaling by αvβ3 integrins in human breast carcinoma cells

5 September 2018

1 reference

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Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma

5 September 2018

1 reference

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Regulation of insulin-like growth factor I receptor dephosphorylation by SHPS-1 and the tyrosine phosphatase SHP-2.

5 September 2018

1 reference

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Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development

5 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FFEBS.12160

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12160

Characterization of the high affinity cell-binding domain in the cell surface proteoglycan syndecan-4

21 January 2018

1 reference

12 December 2020

Recent advances in alphavbeta3 integrin inhibitors

1 reference

12 December 2020

Immunohistochemical analysis of integrin alpha vbeta3 expression on tumor-associated vessels of human carcinomas

1 reference

12 December 2020

Integrin alpha V beta 3 expression by bone-residing breast cancer metastases

1 reference

12 December 2020

Basic fibroblast growth factor increases expression of the alpha v beta 3 integrin complex on human microvascular endothelial cells

1 reference

12 December 2020

Definition of Two Angiogenic Pathways by Distinct alpha(v) Integrins

1 reference

12 December 2020

Identifiers

DOI

10.1111/FEBS.12160

1 reference

16 August 2017

1 reference

16 August 2017

1 reference

PMCID

3651771