The pivotal role of RhoA GTPase in the molecular signaling of axon growth inhibition after CNS injury and targeted therapeutic strategies (Q36822307)

16 August 2017

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title

The pivotal role of RhoA GTPase in the molecular signaling of axon growth inhibition after CNS injury and targeted therapeutic strategies (English)

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16 August 2017

Robert E Gross

1

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16 August 2017

Qi Mei

series ordinal

2

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16 August 2017

Claire-Anne Gutekunst

series ordinal

3

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16 August 2017

Enrique Torre

series ordinal

4

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16 August 2017

publication date

1 January 2007

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16 August 2017

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16 August 2017

volume

16

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16 August 2017

issue

3

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16 August 2017

page(s)

245-262

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Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.

16 August 2017

cites work

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Neuronal responses to myelin are mediated by rho kinase

21 January 2018

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Regulation and functions of Rho-associated kinase

21 January 2018

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Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Cocaine-induced expression changes of axon guidance molecules in the adult rat brain

21 January 2018

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Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Extension and regeneration of corticospinal axons after early spinal injury and the maintenance of corticospinal topography.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Effect of focal cerebral infarctions on lesional RhoA and RhoB expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Chondroitinase ABC promotes functional recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

The role of local actin instability in axon formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth

21 January 2018

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https://api.crossref.org/works/10.3727%2F000000007783464740

Getting RIP'd Stunts Your Growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Prolonged lesional expression of RhoA and RhoB following spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Regeneration of adult axons in white matter tracts of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Myelin-associated glycoprotein inhibits axonal regeneration from a variety of neurons via interaction with a sialoglycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Structural bases for CRMP function in plexin-dependent semaphorin3A signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Injury-induced class 3 semaphorin expression in the rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

The glial scar and central nervous system repair

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Activated macrophages and the blood-brain barrier: inflammation after CNS injury leads to increases in putative inhibitory molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Repulsive factors and axon regeneration in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Axon guidance: GTPases help axons reach their targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Regulation of growth cone actin filaments by guidance cues

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

The role of the Rho GTPases in neuronal development

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Nogo-66 receptor antagonist peptide promotes axonal regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Signalling mechanisms mediating neuronal responses to guidance cues

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

RGMa inhibition promotes axonal growth and recovery after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

The Nogo signaling pathway for regeneration block

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Demonstration of the potential for chronically injured neurons to regenerate axons into intraspinal peripheral nerve grafts

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Nogo receptor mRNA expression in intact and regenerating CNS neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Contact inhibition in the failure of mammalian CNS axonal regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Axon regeneration in young adult mice lacking Nogo-A/B.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Regulation of rho GTPases by crosstalk and neuronal activity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Rho GTPases in neuronal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Axon regeneration: it's getting crowded at the gates of TROY.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Targeting Rho to stimulate repair after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Chimaerins act downstream from neurotrophins in overcoming the inhibition of neurite outgrowth produced by myelin-associated glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Meningeal cell-derived semaphorin 3A inhibits neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Cellular motility driven by assembly and disassembly of actin filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Inhibitor of neurite outgrowth in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Spinal axon regeneration induced by elevation of cyclic AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Secreted semaphorins modulate synaptic transmission in the adult hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Inhibition of myosin light chain kinase by p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Degeneration and regeneration of axons in the lesioned spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Versican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/NgR-independent pathways that converge at RhoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Regeneration beyond the glial scar

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Signaling the pathway to regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Suppression of p75NTR does not promote regeneration of injured spinal cord in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Characterization of new cell permeable C3-like proteins that inactivate Rho and stimulate neurite outgrowth on inhibitory substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Neuroscience. It takes more than two to Nogo

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI.

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

CRMP-2 induces axons in cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

Chronic Enhancement of the Intrinsic Growth Capacity of Sensory Neurons Combined with the Degradation of Inhibitory Proteoglycans Allows Functional Regeneration of Sensory Axons through the Dorsal Root Entry Zone in the Mammalian Spinal Cord

21 January 2018

1 reference

https://api.crossref.org/works/10.3727%2F000000007783464740

10.3727/000000007783464740

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference