Data-derived safety factors for the evaluation of food additives and environmental contaminants (Q36767849)

16 August 2017

Data-derived safety factors for the evaluation of food additives and environmental contaminants (English)

1 reference

16 August 2017

Renwick AG

1

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16 August 2017

1 May 1993

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Food Additives and Contaminants

16 August 2017

1 reference

16 August 2017

10

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16 August 2017

3

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16 August 2017

275-305

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Effects of amlodipine, a long-acting dihydropyridine calcium antagonist in aging hypertension: pharmacodynamics in relation to disposition

16 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Predicting toxicokinetic parameters in humans from toxicokinetic data acquired from three small mammalian species

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Acetaminophen hepatotoxicity: correspondence of selective protein arylation in human and mouse liver in vitro, in culture, and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

A population study of the pharmacokinetics of felodipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Concentration-response relationships for salicylate-induced ototoxicity in normal volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

The human relevance of the renal tumor-inducing potential of d-limonene in male rats: implications for risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Toxic effects of chemicals: difficulties in extrapolating data from animals to man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Inter- and intraindividual variability in the concentration-effect (sedation) relationship of flunitrazepam

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Interindividual differences in the activation of two hepatic carcinogens to mutagens by human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Human variability in susceptibility to toxic chemicals--a preliminary analysis of pharmacokinetic data from normal volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

The metabolism of aspirin in man: a population study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Acceptable daily intake: Inception, evolution, and application

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Interspecies comparisons in toxicology: the utility and futility of plasma concentrations of the test substance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

A pharmacokinetic-pharmacodynamic model of heart rate during cocaine administration in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

The disposition of saccharin in animals and man--a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Safety factors and establishment of acceptable daily intakes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

A data-derived safety (uncertainty) factor for the intense sweetener, saccharin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

The fate of cyclamate in man and other species

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

The pharmacokinetics of oral nifedipine--a population study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

The metabolism of debrisoquine in man: (1) regioselectivity of hydroxylation and (2) aberrant oxidative metabolism in two sibling patients with carbimazole-induced agranulocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Criteria for setting quantitative estimates of acceptable intakes of chemicals in food in the U.K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Extrapolation from animals to man: predictions, pitfalls and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Role of pharmacokinetics in safety evaluation and regulatory considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

The concept of the acceptable daily intake: an historical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Advances in the safety evaluation of food additives. A conceptual and historical overview of the Acceptable Daily Intake (ADI) and Acceptable Daily Intake 'not specified'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

Species Differences in Microsomal Monooxygenase Activity and Their Relationship to Biological Half-Lives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

21 January 2018

Aluminium toxicokinetics

1 reference

https://api.crossref.org/works/10.1080%2F02652039309374152

10.1080/02652039309374152

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

8359312