Review of clinical trials for mitochondrial disorders: 1997-2012. (Q36762846)

16 August 2017

1 reference

title

Review of clinical trials for mitochondrial disorders: 1997-2012. (English)

1 reference

16 August 2017

Douglas S Kerr

1

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16 August 2017

1 April 2013

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16 August 2017

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16 August 2017

10

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16 August 2017

2

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16 August 2017

307-319

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https://scigraph.springernature.com/pub.10.1007/s13311-013-0176-7

16 August 2017

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Spectrum of neurological and survival outcomes in pyruvate dehydrogenase complex (PDC) deficiency: lack of correlation with genotype

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EPI-743 reverses the progression of the pediatric mitochondrial disease--genetically defined Leigh Syndrome.

29 September 2017

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Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders

29 September 2017

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Treatment for mitochondrial disorders

29 September 2017

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Restoration of impaired nitric oxide production in MELAS syndrome with citrulline and arginine supplementation.

29 September 2017

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CoQ(10) deficiencies and MNGIE: two treatable mitochondrial disorders

29 September 2017

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Initial experience in the treatment of inherited mitochondrial disease with EPI-743.

29 September 2017

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A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy

29 September 2017

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Assessment of neurological efficacy of idebenone in pediatric patients with Friedreich's ataxia: data from a 6-month controlled study followed by a 12-month open-label extension study

29 September 2017

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Why are there no proven therapies for genetic mitochondrial diseases?

29 September 2017

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The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?

29 September 2017

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A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia

29 September 2017

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29 September 2017

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Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade

29 September 2017

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Idebenone: an emerging therapy for Friedreich ataxia

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Human CoQ10 deficiencies

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A critical approach to the therapy of mitochondrial respiratory chain and oxidative phosphorylation diseases

29 September 2017

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How can we treat mitochondrial encephalomyopathies? Approaches to therapy

29 September 2017

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Leigh and Leigh-like syndrome in children and adults

29 September 2017

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New indications and controversies in arginine therapy

29 September 2017

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Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial

29 September 2017

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MELAS and L-arginine therapy

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease

29 September 2017

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Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Clinical trials of coenzyme Q10 in neurological disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Chronic treatment of mitochondrial disease patients with dichloroacetate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

A placebo-controlled crossover trial of creatine in mitochondrial diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Treatment of congenital lactic acidosis with dichloroacetate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

31P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo-controlled, double-blind 31P-MRS crossover study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Brain uptake of Tc99m-HMPAO correlates with clinical response to the novel redox modulating agent EPI-743 in patients with mitochondrial disease.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

A randomized trial of coenzyme Q10 in mitochondrial disorders

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Resistance training in patients with single, large-scale deletions of mitochondrial DNA.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Endothelial dysfunction in MELAS improved by l-arginine supplementation.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

L-arginine improves the symptoms of strokelike episodes in MELAS.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3625388

Aerobic conditioning in patients with mitochondrial myopathies: physiological, biochemical, and genetic effects

5 September 2018

1 reference

12 December 2020

A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies

1 reference

12 December 2020

Nerve conduction abnormalities in patients with MELAS and the A3243G mutation

1 reference

12 December 2020

Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial

1 reference

12 December 2020

10.1007/S13311-013-0176-7

Identifiers

DOI

1 reference

16 August 2017

1 reference

16 August 2017

1 reference

PMCID

3625388