Combinatorial RNAi: a winning strategy for the race against evolving targets? (Q36740351)

16 August 2017

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title

Combinatorial RNAi: a winning strategy for the race against evolving targets? (English)

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16 August 2017

1

Dirk Grimm

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16 August 2017

Mark A Kay

2

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16 August 2017

20 February 2007

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16 August 2017

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16 August 2017

15

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16 August 2017

878-888

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16 August 2017

5

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Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

16 August 2017

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12 December 2020

Use of RNA polymerase II to transcribe artificial microRNAs.

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12 December 2020

New microRNAs from mouse and human

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12 December 2020

A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference.

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12 December 2020

Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration

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12 December 2020

Human immunodeficiency virus type 1 escape from RNA interference

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12 December 2020

HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome

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12 December 2020

Artificial control of gene expression in mammalian cells by modulating RNA interference through aptamer-small molecule interaction

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12 December 2020

Cloning and detection of HIV-1-encoded microRNA.

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12 December 2020

Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing.

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12 December 2020

A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses

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12 December 2020

Paradigms for conditional expression of RNA interference molecules for use against viral targets.

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12 December 2020

Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components

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12 December 2020

A single siRNA suppresses fatal encephalitis induced by two different flaviviruses

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12 December 2020

Down-regulation of viral replication by adenoviral-mediated expression of siRNA against cellular cofactors for hepatitis C virus

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12 December 2020

Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA.

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12 December 2020

Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA.

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12 December 2020

Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice

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12 December 2020

Hepatitis C virus core protein is a potent inhibitor of RNA silencing-based antiviral response

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12 December 2020

Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors

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12 December 2020

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

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12 December 2020

Inhibition of foot-and-mouth disease virus replication by small interfering RNA.

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12 December 2020

Intracellular-diced dsRNA has enhanced efficacy for silencing HCV RNA and overcomes variation in the viral genotype

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12 December 2020

Identification of virus-encoded microRNAs

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12 December 2020

Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor

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12 December 2020

Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes

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12 December 2020

Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing

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12 December 2020

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12 December 2020

H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity.

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12 December 2020

Identification of microRNAs of the herpesvirus family

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12 December 2020

Induction and suppression of RNA silencing: insights from viral infections

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12 December 2020

Silencing of HIV-1 with RNA interference: a multiple shRNA approach

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12 December 2020

Simultaneous targeting of HCV replication and viral binding with a single lentiviral vector containing multiple RNA interference expression cassettes.

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12 December 2020

MicroRNAs: expression, avoidance and subversion by vertebrate viruses

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12 December 2020

Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance

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12 December 2020

HIV-1 TAR RNA subverts RNA interference in transfected cells through sequestration of TAR RNA-binding protein, TRBP

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12 December 2020

Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches

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12 December 2020

Regulation of human immunodeficiency virus 1 transcription by nef microRNA.

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12 December 2020

Amplification of RNAi--targeting HLA mRNAs.

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12 December 2020

Hairpin ribozymes in combination with siRNAs against highly conserved hepatitis C virus sequence inhibit RNA replication and protein translation from hepatitis C virus subgenomic replicons

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12 December 2020

Unlocking the potential of the human genome with RNA interference

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12 December 2020

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

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12 December 2020

Suppression of RNA interference by adenovirus virus-associated RNA.

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12 December 2020

Stealth and cunning: hepatitis B and hepatitis C viruses

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12 December 2020

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

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12 December 2020

Breakthrough of the year. Small RNAs make big splash

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12 December 2020

Inhibition of respiratory viruses by nasally administered siRNA.

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12 December 2020

A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression

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12 December 2020

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

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12 December 2020

Short interfering RNA confers intracellular antiviral immunity in human cells

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12 December 2020

Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs

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12 December 2020

Viruses and microRNAs

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12 December 2020

Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape.

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12 December 2020

Hepatitis C Virus Replicons Escape RNA Interference Induced by a Short Interfering RNA Directed against the NS5b Coding Region

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12 December 2020

Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein.

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12 December 2020

Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown

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12 December 2020

Simultaneous inhibition of GSK3alpha and GSK3beta using hairpin siRNA expression vectors.

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12 December 2020

A versatile tool for conditional gene expression and knockdown

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12 December 2020

Interaction of viruses with the mammalian RNA interference pathway

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12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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12 December 2020

An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi

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12 December 2020

Is RNA interference involved in intrinsic antiviral immunity in mammals?

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12 December 2020

Inhibition of severe acute respiratory syndrome virus replication by small interfering RNAs in mammalian cells

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12 December 2020

SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells

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12 December 2020

Adenovirus virus-associated RNA and translation control

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12 December 2020

Control of HIV-1 replication by RNA interference

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12 December 2020

Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis

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12 December 2020

Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy

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12 December 2020

Silencing Viral Infection

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12 December 2020

Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1.

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12 December 2020

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

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12 December 2020

Antiviral RNAi therapy: emerging approaches for hitting a moving target

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12 December 2020

Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV

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12 December 2020

Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.

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12 December 2020

Tuning silence: conditional systems for RNA interference

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12 December 2020

Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

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12 December 2020

Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

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12 December 2020

Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155.

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12 December 2020

The causes and consequences of HIV evolution

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12 December 2020

Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors

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12 December 2020

Therapeutic short hairpin RNA expression in the liver: viral targets and vectors

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12 December 2020

Noise amidst the silence: off-target effects of siRNAs?

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12 December 2020

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

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12 December 2020

Identifiers

DOI

10.1038/SJ.MT.6300116

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16 August 2017

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PubMed ID

17311009