Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. (Q36736233)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10449442%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

title

Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD (English)

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11 December 2019

1 reference

3

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11 December 2019

author name string

S Srivastava

1

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11 December 2019

M N Weitzmann

2

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11 December 2019

F P Ross

4

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11 December 2019

S Adler

5

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11 December 2019

R Pacifici

6

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11 December 2019

language of work or name

English

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publication date

1 August 1999

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Journal of Clinical Investigation

11 December 2019

published in

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11 December 2019

volume

104

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11 December 2019

issue

4

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11 December 2019

page(s)

503-513

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Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1.

11 December 2019

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

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Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

29 September 2017

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Transcriptional regulation of estrogen-responsive genes by non-steroidal estrogens: doisynolic and allenolic acids

29 September 2017

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Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNF alpha

29 September 2017

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Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.

29 September 2017

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Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors

29 September 2017

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29 September 2017

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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.

29 September 2017

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29 September 2017

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Casein kinase II associates with Egr-1 and acts as a negative modulator of its DNA binding and transcription activities in NIH 3T3 cells

29 September 2017

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Selective interaction of JNK protein kinase isoforms with transcription factors

29 September 2017

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Cloning of a novel receptor expressed in rat prostate and ovary

29 September 2017

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Cytokines and estrogen in bone: anti-osteoporotic effects

29 September 2017

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Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein

29 September 2017

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

29 September 2017

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Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice

29 September 2017

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Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis

29 September 2017

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A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1 beta gene

29 September 2017

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Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta

29 September 2017

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An interleukin 1 like factor stimulates bone resorption in vitro.

29 September 2017

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29 September 2017

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Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by phorbol myristate acetate and anti-CD3 antibody

29 September 2017

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The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells

29 September 2017

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A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines

29 September 2017

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29 September 2017

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The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

29 September 2017

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29 September 2017

12 December 2020

Cytokines and transcription factors

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The regulation of transcription by phosphorylation

29 September 2017

1 reference

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Modulation of osteoclast differentiation

29 September 2017

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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

29 September 2017

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Conditions controlling the proliferation of haemopoietic stem cells in vitro

29 September 2017

1 reference

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Estrogen modulates the expression of tumor necrosis factor alpha mRNA in phorbol ester-stimulated human monocytic THP-1 cells.

29 September 2017

1 reference

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Transcriptional regulation in the immune system: all roads lead to AP-1.

29 September 2017

1 reference

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Regulation and function of the JNK subgroup of MAP kinases

28 June 2018

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Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2.

28 June 2018

1 reference

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Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens

28 June 2018

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Production of interleukin-6 in human osteoblasts and human bone marrow stromal cells: evidence that induction by interleukin-1 and tumor necrosis factor-alpha is not regulated by ovarian steroids

28 June 2018

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Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha

28 June 2018

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Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women.

28 June 2018

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Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages

28 June 2018

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The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines

28 June 2018

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Transrepression of c-jun gene expression by the glucocorticoid receptor requires both AP-1 sites in the c-jun promoter

28 June 2018

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Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells

5 September 2018

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12 December 2020

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

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12 December 2020

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

1 reference

12 December 2020

Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production

1 reference

12 December 2020

The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice

1 reference

12 December 2020

A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro

1 reference

12 December 2020

Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer

1 reference

12 December 2020

Analysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced cytokine expression in postmenopausal osteoporosis

1 reference

12 December 2020

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

1 reference

12 December 2020

Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation

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12 December 2020

Positive and negative effects of nuclear receptors on transcription activation by AP-1 of the human choline acetyltransferase proximal promoter

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12 December 2020

Identifiers

DOI

10.1172/JCI7094

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10449442%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10449442%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

1 reference