Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate (Q36727361)

15 August 2017

Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate (English)

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15 August 2017

2

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10 June 2020

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Klaus Klaushofer

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10 June 2020

15

Andre J van Wijnen

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10 June 2020

author name string

Roman Thaler

1

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10 June 2020

Paul Roschger

3

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10 June 2020

Ines Sturmlechner

4

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10 June 2020

Farzaneh Khani

5

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10 June 2020

Silvia Spitzer

6

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10 June 2020

Monika Rumpler

7

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10 June 2020

Jochen Zwerina

8

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10 June 2020

Heidrun Karlic

9

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10 June 2020

Amel Dudakovic

10

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10 June 2020

Anna Teti

12

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10 June 2020

Nadia Rucci

13

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10 June 2020

Franz Varga

14

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10 June 2020

language of work or name

English

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publication date

12 January 2016

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Journal of Biological Chemistry

15 August 2017

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10 June 2020

volume

291

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10 June 2020

page(s)

6754-6771

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10 June 2020

issue

13

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describes a project that uses

10 June 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

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30 September 2017

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30 September 2017

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HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

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MicroRNA functions in osteogenesis and dysfunctions in osteoporosis

30 September 2017

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Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells

30 September 2017

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Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells

30 September 2017

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Homocysteine induces serum amyloid A3 in osteoblasts via unlocking RGD-motifs in collagen

30 September 2017

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A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level

30 September 2017

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DMSO is a strong inducer of DNA hydroxymethylation in pre-osteoblastic MC3T3-E1 cells

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Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells

30 September 2017

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Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation

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30 September 2017

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Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adults

30 September 2017

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Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds

30 September 2017

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30 September 2017

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Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

1 reference

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Dimethyl sulfoxide has an impact on epigenetic profile in mouse embryoid body

30 September 2017

1 reference

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BMP signaling and skeletogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Induction of Osteoclast Differentiation by Runx2 through Receptor Activator of Nuclear Factor-κB Ligand (RANKL) and Osteoprotegerin Regulation and Partial Rescue of Osteoclastogenesis in Runx2–/– Mice by RANKL Transgene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

A new mathematical model for relative quantification in real-time RT-PCR

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide

30 September 2017

1 reference

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Real-time digital median frequency estimator for surface myoelectric signals

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Matrix mineralization in MC3T3-E1 cell cultures initiated by beta-glycerophosphate pulse.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Inhibition of bone remodeling in young mice by bisphosphonate displaces the plasma cell niche into the spleen.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Annual intravenous zoledronic acid for three years increased cancellous bone matrix mineralization beyond normal values in the HORIZON biopsy cohort.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Simultaneous determination of glucoraphanin and sulforaphane in Brassica oleracea seeds by high-performance liquid chromatography with evaporative light-scattering detector

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor-kappaB.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Regulation of osteoclast differentiation and function by receptor activator of NFkB ligand and osteoprotegerin.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Sulforaphane protects human chondrocytes against cell death induced by various stimuli

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4807263

Bisphosphonate Use and Atypical Fractures of the Femoral Shaft

20 October 2018

1 reference

12 December 2020

The appearance of phospholipase and cyclo-oxygenase activities in the human promyelocytic leukemia cell line HL60 during dimethyl sulfoxide-induced differentiation

1 reference

12 December 2020

Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies

1 reference

12 December 2020

Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M115.678235

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26757819%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26757819%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference