Effect of PSI-697, a novel P-selectin inhibitor, on platelet-monocyte aggregate formation in humans (Q36701850)

15 August 2017

Effect of PSI-697, a novel P-selectin inhibitor, on platelet-monocyte aggregate formation in humans (English)

1 reference

15 August 2017

12

David E Newby

1 reference

ORCID Public Data File 2021

15 August 2017

1 reference

author name string

Alan G Japp

1

1 reference

15 August 2017

Raj Chelliah

2

1 reference

15 August 2017

Laura Tattersall

3

1 reference

15 August 2017

Ninian N Lang

4

1 reference

15 August 2017

Xu Meng

5

1 reference

15 August 2017

Kathleen Weisel

6

1 reference

15 August 2017

Arie Katz

7

1 reference

15 August 2017

David Burt

8

1 reference

15 August 2017

Keith A A Fox

9

1 reference

15 August 2017

Giora Z Feuerstein

10

1 reference

15 August 2017

Thomas M Connolly

11

1 reference

15 August 2017

28 January 2013

1 reference

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

15 August 2017

1 reference

15 August 2017

2

1 reference

15 August 2017

1

1 reference

15 August 2017

e006007

1 reference

P-selectin antagonism reduces thrombus formation in humans.

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Platelet function testing in cardiovascular diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

The adhesion molecule P-selectin and cardiovascular disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

A functional epitope on P-selectin that supports binding of P-selectin to P-selectin glycoprotein ligand-1 but not to sialyl Lewis X oligosaccharides

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

P-selectin induces the expression of tissue factor on monocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Selectins: interpreters of cell-specific carbohydrate information during inflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Pretreatment with a blocking monoclonal antibody to P-selectin accelerates pharmacological thrombolysis in a primate model of arterial thrombosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Flow cytometric analysis of circulating platelet-monocyte aggregates in whole blood: methodological considerations

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Increased CD40 ligand and platelet-monocyte aggregates in patients with type 1 diabetes mellitus.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Upregulation of the CD40/CD40 ligand dyad and platelet-monocyte aggregation in cigarette smokers

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Effects of efonidipine on platelet and monocyte activation markers in hypertensive patients with and without type 2 diabetes mellitus

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3603266

Increased Platelet Binding to Circulating Monocytes in Acute Coronary Syndromes

5 September 2018

1 reference

12 December 2020

Platelet-leukocyte interaction: selective binding of thrombin-stimulated platelets to human monocytes, polymorphonuclear leukocytes, and related cell lines

1 reference

12 December 2020

Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

1 reference

12 December 2020

P-selectin and TNF inhibition reduce venous thrombosis inflammation

1 reference

12 December 2020

Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets

1 reference

12 December 2020

Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease

1 reference

12 December 2020

Low-dose aspirin does not lowerin vivoplatelet activation in healthy smokers

1 reference

12 December 2020

Smoking is associated with advanced coronary atherosclerosis in youth

1 reference

12 December 2020

Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis

1 reference

12 December 2020

2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists

1 reference

12 December 2020

Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation

1 reference

12 December 2020

Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions

1 reference

12 December 2020

Identifiers

DOI

10.1161/JAHA.112.006007

1 reference

15 August 2017

1 reference

15 August 2017

1 reference