The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance. (Q36685564)

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23 December 2019

review article

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title

The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance (English)

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23 December 2019

2

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23 December 2019

author name string

Francisco Borrego

1

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23 December 2019

Alina I Marusina

3

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23 December 2019

Xiaobin Tang

4

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23 December 2019

John E Coligan

5

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23 December 2019

publication date

1 January 2006

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23 December 2019

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23 December 2019

volume

35

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23 December 2019

page(s)

263-278

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23 December 2019

issue

3

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https://scigraph.springernature.com/pub.10.1385/ir:35:3:263

23 December 2019

exact match

0 references

cites work

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NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor

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IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism

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Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts

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Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection

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Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors

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KIR expression on self-reactive CD8+ T cells is controlled by T-cell receptor engagement

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The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

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12 December 2020

Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)

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12 December 2020

Differential expression of inhibitory or activating CD94/NKG2 subtypes on MART-1-reactive T cells in vitiligo versus melanoma: a case report

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A multigene family on human chromosome 12 encodes natural killer-cell lectins

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Mouse Ly49 NK receptors: balancing activation and inhibition

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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

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Imaging immune surveillance by T cells and NK cells

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What is the importance of the immunological synapse?

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HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells

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Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors

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Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2.

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12 December 2020

NK cell-mediated lysis of autologous HCMV-infected skin fibroblasts is highly variable among NK cell clones and polyclonal NK cell lines

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12 December 2020

NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect

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GATA-3 is an important transcription factor for regulating human NKG2A gene expression

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12 December 2020

Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes

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12 December 2020

Qa-1, a nonclassical class I histocompatibility molecule with roles in innate and adaptive immunity

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12 December 2020

Differential effects of US2, US6 and US11 human cytomegalovirus proteins on HLA class Ia and HLA-E expression: impact on target susceptibility to NK cell subsets

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Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells.

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Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis

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Internalization and intracellular fate of TCR-CD3 complexes

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A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6.

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12 December 2020

Expression of CD94/NKG2A and killer immunoglobulin-like receptors in NK cells and a subset of extranodal cytotoxic T-cell lymphomas

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12 December 2020

The NKG2 natural killer cell receptor family: comparative analysis of promoter sequences.

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HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A

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12 December 2020

Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E

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12 December 2020

Regulation of the natural killer cell receptor repertoire

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12 December 2020

Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue

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12 December 2020

Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection: lack of reversion with highly active antiretroviral therapy

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12 December 2020

Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors

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12 December 2020

HCMV glycoprotein US6 mediated inhibition of TAP does not affect HLA-E dependent protection of K-562 cells from NK cell lysis

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12 December 2020

Roles of the NKG2D immunoreceptor and its ligands

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12 December 2020

Qa-1b binds conserved class I leader peptides derived from several mammalian species

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12 December 2020

Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway

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12 December 2020

Differential regulation of killer cell Ig-like receptors and CD94 lectin-like dimers on NK and T lymphocytes from HIV-1-infected individuals

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12 December 2020

Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells

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12 December 2020

CD94-NKG2A receptors regulate antiviral CD8(+) T cell responses.

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12 December 2020

Up-regulation of Inhibitory Natural Killer Receptors CD94/NKG2A with Suppressed Intracellular Perforin Expression of Tumor-Infiltrating CD8+T Lymphocytes in Human Cervical Carcinoma

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12 December 2020

CD94/NKG2A inhibits NK cell activation by disrupting the actin network at the immunological synapse

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12 December 2020

Preferential survival of CD8 T and NK cells expressing high levels of CD94

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12 December 2020

CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features

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12 December 2020

The immunological synapse.

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12 December 2020

Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis

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12 December 2020

CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells

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12 December 2020

NK cell CD94/NKG2A inhibitory receptors are internalized and recycle independently of inhibitory signaling processes

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12 December 2020

Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets.

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12 December 2020

Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts.

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12 December 2020

Transforming growth factor-beta-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes

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12 December 2020

Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants

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12 December 2020

Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells.

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12 December 2020

Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses

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12 December 2020

Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics

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12 December 2020

Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation.

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12 December 2020

The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA-E through mostly shared but partly distinct sets of HLA-E residues

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12 December 2020

Endocytosis and molecular sorting

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12 December 2020

NK-associated receptors on CD8 T cells from treatment-naive HIV-infected individuals: defective expression of CD56

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12 December 2020

The human CD94 gene encodes multiple, expressible transcripts including a new partner of NKG2A/B.

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12 December 2020

Structural basis for a major histocompatibility complex class Ib-restricted T cell response

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12 December 2020

The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

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12 December 2020

HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer

1 reference

12 December 2020

Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases

1 reference

12 December 2020

Renal cell carcinoma-infiltrating natural killer cells express differential repertoires of activating and inhibitory receptors and are inhibited by specific HLA class I allotypes

1 reference

12 December 2020

Qa-1b and CD94-NKG2a interaction regulate cytolytic activity of herpes simplex virus-specific memory CD8+ T cells in the latently infected trigeminal ganglia

1 reference

12 December 2020

A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2

1 reference

12 December 2020

CD94 transcripts imply a better prognosis in nasal-type extranodal NK/T-cell lymphoma

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12 December 2020

Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking

1 reference

12 December 2020

IL-21 induces the functional maturation of murine NK cells

1 reference

12 December 2020

The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing

1 reference

12 December 2020

Mitogen-activated protein kinase activity is involved in effector functions triggered by the CD94/NKG2-C NK receptor specific for HLA-E.

1 reference

12 December 2020

The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex

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12 December 2020

TCR specificity dictates CD94/NKG2A expression by human CTL.

1 reference

12 December 2020

Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering

1 reference

12 December 2020

Structure of the human CD94 C-type lectin gene

1 reference

12 December 2020

Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E.

1 reference

12 December 2020

Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene.

1 reference

12 December 2020

CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells

1 reference

12 December 2020

Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates

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12 December 2020

HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells.

1 reference

12 December 2020

Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity

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12 December 2020

KIR down-regulation on NK cells is associated with down-regulation of activating receptors and NK cell inactivation

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12 December 2020

1 reference

12 December 2020

Synergistic effect of IFN-gamma and human cytomegalovirus protein UL40 in the HLA-E-dependent protection from NK cell-mediated cytotoxicity

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12 December 2020

Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits

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12 December 2020

Analysis of Qa-1(b) peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa-1-peptide complexes

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12 December 2020

Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions.

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12 December 2020

Human natural killer cells with polyclonal lectin and immunoglobulinlike receptors develop from single hematopoietic stem cells with preferential expression of NKG2A and KIR2DL2/L3/S2.

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12 December 2020

Transcriptional Control of MurineCD94Gene: Differential Usage of Dual Promoters by Lymphoid Cell Types

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12 December 2020

Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphism

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12 December 2020

Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells

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12 December 2020

CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes

1 reference

12 December 2020

Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors

1 reference

12 December 2020

Phenotypic and functional analysis of the HLA-class I-specific inhibitory receptors of natural killer cells isolated from peripheral blood of patients undergoing bone marrow transplantation from matched unrelated donors

1 reference

12 December 2020

Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells

1 reference

12 December 2020

Association of DAP12 with activating CD94/NKG2C NK cell receptors

1 reference

12 December 2020

Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors

1 reference

12 December 2020

TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide

1 reference

12 December 2020

Exclusion of lipid rafts and decreased mobility of CD94/NKG2A receptors at the inhibitory NK cell synapse

1 reference

12 December 2020

Expression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3-mediated stimulation

1 reference

12 December 2020

Implications of HLA-E allele expression and different HLA-E ligand diversity for the regulation of NK cells

1 reference

12 December 2020

A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition

1 reference

12 December 2020

Studying protein dynamics in living cells

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12 December 2020

Differential regulation of human NK cell-associated gene expression following activation by IL-2, IFN-alpha and PMA/ionomycin

1 reference

12 December 2020

Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

1 reference

12 December 2020

HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities

1 reference

12 December 2020

Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: the role of endogenous class I major histocompatibility complex and a viral class I homolog

1 reference

12 December 2020

Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses.

1 reference

12 December 2020

UL40-mediated NK evasion during productive infection with human cytomegalovirus.

1 reference

12 December 2020

Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine

1 reference

12 December 2020

Reconstitution of NK cell receptor repertoire following HLA-matched hematopoietic cell transplantation

1 reference

12 December 2020

Identifiers

DOI

10.1385/IR:35:3:263

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17172651%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

23 December 2019

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