Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B. (Q36672710)

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22 February 2020

title

Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B (English)

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22 February 2020

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22 February 2020

Jérôme Gouttenoire

4

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22 February 2020

Marco Binder

8

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22 February 2020

Darius Moradpour

10

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22 February 2020

Ralf Bartenschlager

11

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22 February 2020

Wolfgang Stremmel

13

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22 February 2020

Volker Lohmann

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22 February 2020

author name string

Katharina Esser-Nobis

1

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22 February 2020

Tom M Ganten

3

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22 February 2020

Christian Harak

5

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22 February 2020

Rahel Klein

6

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22 February 2020

Peter Schemmer

7

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22 February 2020

Paul Schnitzler

9

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22 February 2020

Stephen J Polyak

12

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22 February 2020

François Penin

14

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22 February 2020

Christoph Eisenbach

15

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22 February 2020

language of work or name

English

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publication date

7 February 2013

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22 February 2020

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22 February 2020

volume

57

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22 February 2020

page(s)

953-963

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22 February 2020

issue

3

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Failure of Intravenous Silibinin Monotherapy to Prevent Hepatitis C Genotype 2A Liver Graft Reinfection

22 February 2020

cites work

1 reference

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Antiviral strategies in hepatitis C virus infection

30 September 2017

1 reference

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NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes

30 September 2017

1 reference

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Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation

30 September 2017

1 reference

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Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment

30 September 2017

1 reference

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The Future of HCV Therapy: NS4B as an Antiviral Target

30 September 2017

1 reference

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Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B

30 September 2017

1 reference

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Identification of hepatoprotective flavonolignans from silymarin

30 September 2017

1 reference

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Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory

30 September 2017

1 reference

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Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase

30 September 2017

1 reference

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Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C

30 September 2017

1 reference

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An Amphipathic -Helix at the C Terminus of Hepatitis C Virus Nonstructural Protein 4B Mediates Membrane Association

30 September 2017

1 reference

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A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication

30 September 2017

1 reference

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Identification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase Chimeras

30 September 2017

1 reference

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Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells

30 September 2017

1 reference

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Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

30 September 2017

1 reference

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Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

30 September 2017

1 reference

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

30 September 2017

1 reference

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Safety and anti-HCV effect of prolonged intravenous silibinin in HCV genotype 1 subjects in the immediate liver transplant period

30 September 2017

1 reference

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High-dose silibinin rescue treatment for HCV-infected patients showing suboptimal virologic response to standard combination therapy.

20 September 2018

1 reference

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Intravenous silibinin as 'rescue treatment' for on-treatment non-responders to pegylated interferon/ribavirin combination therapy

20 September 2018

1 reference

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Treatment of hepatitis C-virus-reinfection after liver transplant with silibinin in nonresponders to pegylated interferon-based therapy

20 September 2018

1 reference

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Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient

20 September 2018

1 reference

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Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy

20 September 2018

1 reference

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Rapid suppression of hepatitis C viremia induced by intravenous silibinin plus ribavirin

20 September 2018

1 reference

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Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593759

Influence of silybin on biophysical properties of phospholipid bilayers

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23322644

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23322644

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23322644

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/HEP.26260

1 reference

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22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23322644%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23322644%20AND%20SRC:MED&resulttype=core&format=json