Genomic impact of transient low-dose decitabine treatment on primary AML cells (Q36654140)

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21 February 2020

title

Genomic impact of transient low-dose decitabine treatment on primary AML cells (English)

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11

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15

Elaine R Mardis

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7

Jasreet Hundal

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Nobish Varghese

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Todd Wylie

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Tamara L Lamprecht

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Jeffery M Klco

1

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David H Spencer

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Shawn M Sarkaria

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Vincent Magrini

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Jason Walker

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Petra Erdmann-Gilmore

10

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Matthew R Meyer

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R Reid Townsend

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Richard K Wilson

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Timothy J Ley

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language of work or name

English

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publication date

7 January 2013

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21 February 2020

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21 February 2020

volume

121

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issue

9

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page(s)

1633-1643

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Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia

21 February 2020

cites work

1 reference

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CpGassoc: an R function for analysis of DNA methylation microarray data

30 September 2017

1 reference

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Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells

30 September 2017

1 reference

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A promoter DNA demethylation landscape of human hematopoietic differentiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

The depletion of DNA methyltransferase-1 and the epigenetic effects of 5-aza-2'deoxycytidine (decitabine) are differentially regulated by cell cycle progression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

30 September 2017

1 reference

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Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines

30 September 2017

1 reference

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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

30 September 2017

1 reference

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DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

30 September 2017

1 reference

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DNMT3A Mutations in Acute Myeloid Leukemia

30 September 2017

1 reference

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Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes

30 September 2017

1 reference

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Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia

30 September 2017

1 reference

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Anthracycline dose intensification in acute myeloid leukemia

30 September 2017

1 reference

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Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

30 September 2017

1 reference

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Targeting DNA methylation

30 September 2017

1 reference

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High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples

30 September 2017

1 reference

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The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

30 September 2017

1 reference

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A human B cell methylome at 100-base pair resolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

lumi: a pipeline for processing Illumina microarray

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia

30 September 2017

1 reference

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Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis

30 September 2017

1 reference

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Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

30 September 2017

1 reference

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Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms

30 September 2017

1 reference

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Characterization of a novel human endogenous retrovirus, HERV-H/F, expressed in human leukemia cell lines

30 September 2017

1 reference

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5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

30 September 2017

1 reference

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Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Cytosine methylation and the ecology of intragenomic parasites

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

High density DNA methylation array with single CpG site resolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Promoter methylation of DAPK1, E-cadherin and thrombospondin-1 in de novo and therapy-related myeloid neoplasms.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587326

Strategies in the treatment of acute myeloid leukemia

20 September 2018

1 reference

12 December 2020

5-Aza-2'-deoxycytidine as a differentiation inducer in acute myeloid leukaemias and myelodysplastic syndromes of the elderly

1 reference

12 December 2020

Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia

1 reference

12 December 2020

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia

1 reference

12 December 2020

P15INK4B gene methylation and expression in normal, myelodysplastic, and acute myelogenous leukemia cells and in the marrow cells of cured lymphoma patients

1 reference

12 December 2020

10.1182/BLOOD-2012-09-459313

Identifiers

DOI

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21 February 2020

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