Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody. (Q36649240)

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scientific article published on June 1993

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English	Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody.	scientific article published on June 1993

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scholarly article

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13 October 2019

Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody (English)

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13 October 2019

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13 October 2019

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N Sullivan

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13 October 2019

author name string

C Furman

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D D Ho

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J Sodroski

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1 June 1993

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13 October 2019

Journal of Virology

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13 October 2019

67

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13 October 2019

6

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13 October 2019

3674-3679

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Europe PubMed Central

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13 October 2019

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1 reference

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Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

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T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

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Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1

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The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

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Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule

1 reference

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Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4.

1 reference

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Effects of anti-gp120 monoclonal antibodies on CD4 receptor binding by the env protein of human immunodeficiency virus type 1

1 reference

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Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

1 reference

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Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.

1 reference

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Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells

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Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants

1 reference

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Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion.

1 reference

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30 September 2017

Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding

1 reference

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Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41

1 reference

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30 September 2017

Evidence for non-V3-specific neutralizing antibodies that interfere with gp120/CD4 binding in human immunodeficiency virus 1-infected humans

1 reference

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30 September 2017

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

1 reference

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30 September 2017

Identification of the principal neutralizing determinant of human immunodeficiency virus type 1 as a fusion domain

1 reference

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30 September 2017

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity

1 reference

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Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity

1 reference

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Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibody

1 reference

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Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody

1 reference

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Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody

1 reference

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Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein

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Mutations in the leucine zipper of the human immunodeficiency virus type 1 transmembrane glycoprotein affect fusion and infectivity

1 reference

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The transmembrane glycoprotein of human immunodeficiency virus type 1 induces syncytium formation in the absence of the receptor binding glycoprotein

1 reference

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Target cell-specific determinants of membrane fusion within the human immunodeficiency virus type 1 gp120 third variable region and gp41 amino terminus

1 reference

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Mutations in the principal neutralization determinant of human immunodeficiency virus type 1 affect syncytium formation, virus infectivity, growth kinetics, and neutralization

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Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

1 reference

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Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein

1 reference

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1 reference

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Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region

1 reference

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Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein.

1 reference

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Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS.

1 reference

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Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients

1 reference

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Human immunodeficiency virus 1. Predominance of a group-specific neutralizing epitope that persists despite genetic variation

1 reference

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Dissociation of gp120 from HIV-1 virions induced by soluble CD4.

1 reference

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Alteration of HIV-1 infectivity and neutralization by a single amino acid replacement in the V3 loop domain

1 reference

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Functional roles of the V3 hypervariable region of HIV-1 gp160 in the processing of gp160 and in the formation of syncytia in CD4+ cells

1 reference

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A human monoclonal antibody against the CD4-binding site of HIV1 gp120 exhibits potent, broadly neutralizing activity

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Identification of two neutralizing and 8 non-neutralizing epitopes on simian immunodeficiency virus envelope using monoclonal antibodies

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Production of human monoclonal antibodies specific for conformational and linear non-V3 epitopes of gp120.

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Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.

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Soluble CD4 and dextran sulfate mediate release of gp120 from HIV-1: implications for clinical trials

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/8497077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.67.6.3674-3679.1993

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8497077%20AND%20SRC:MED&resulttype=core&format=json

13 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8497077%20AND%20SRC:MED&resulttype=core&format=json

13 October 2019

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