Application of biomarkers in the clinical development of new drugs for chondroprotection in destructive joint diseases: a review (Q36631211)

15 August 2017

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title

Application of biomarkers in the clinical development of new drugs for chondroprotection in destructive joint diseases: a review (English)

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15 August 2017

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Sumer EU

1

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15 August 2017

Schaller S

2

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15 August 2017

Sondergaard BC

3

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15 August 2017

Tankó LB

4

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15 August 2017

Qvist P

5

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15 August 2017

1 November 2006

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15 August 2017

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15 August 2017

11

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15 August 2017

6

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15 August 2017

485-506

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An arthritogenic monoclonal antibody to type II collagen, CII-C1, impairs cartilage formation by cultured chondrocytes

15 August 2017

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https://api.crossref.org/works/10.1080%2F13547500600886115

PGE2 signal through EP2 promotes the growth of articular chondrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Osteoblast and osteoclast precursors in primary cultures of calvarial bone cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Metalloproteinase inhibitors and the prevention of connective tissue breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

The influence of alignment on risk of knee osteoarthritis progression according to baseline stage of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Biochemical markers of bone metabolism: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Serum CrossLaps for monitoring the response in individuals undergoing antiresorptive therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Development of an enzyme-linked immunoassay for the quantification of YKL-40 (cartilage gp-39) in guinea pig serum using hen egg yolk antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Molecular markers for osteoarthritis: the road ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Expression of cartilage oligomeric matrix protein (COMP) by embryonic and adult osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

The collagens of articular cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in progressive versus non-progressive osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Towards a molecular understanding of arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Neoepitopes as biomarkers of cartilage catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

The bisphosphonate zoledronate decreases type II collagen breakdown in patients with Paget's disease of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

New developments in biochemical markers for osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Biomarkers in osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Association of baseline levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Urinary excretion of glucosyl-galactosyl pyridinoline: a specific biochemical marker of synovium degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Structure and function of aggrecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

21 January 2018

Cartilage proteoglycans

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Markers for type II collagen breakdown predict the effect of disease-modifying treatment on long-term radiographic progression in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Relationship between serum hyaluronic acid level and disease activity in early rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Serum levels of hyaluronan, antigenic keratan sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid arthritis patients who have begun activity after a night of bed rest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Aging, articular cartilage chondrocyte senescence and osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

The antigenic determinants recognized by three monoclonal antibodies to keratan sulphate involve sulphated hepta- or larger oligosaccharides of the poly(N-acetyllactosamine) series

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Evidence for altered synthesis of type II collagen in patients with osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Interpreting radiographic data in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

The nitrite/collagen reaction: non-enzymatic nitration as a model system for age-related damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Biological markers in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

The contribution of clinical pharmacology surrogates and models to drug development--a critical appraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Phenotypic characterization of chondrosarcoma-derived cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Procollagen II C propeptide level in the synovial fluid as a predictor of radiographic progression in early knee osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Insulin-like growth factors I and II are autocrine factors in stimulating proteoglycan synthesis, a marker of differentiated chondrocytes, acting through their respective receptors on a clonal human chondrosarcoma-derived chondrocyte cell line, HCS-

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Tyrosine modification by reactive nitrogen species: a closer look

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Markers of disease in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Osteoarthritis: Is it a disease of cartilage or of bone?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Soy protein may alleviate osteoarthritis symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13547500600886115

10.1080/13547500600886115

21 January 2018

Identifiers

DOI

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15 August 2017

1 reference