Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine (Q36625874)

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3 January 2020

title

Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine (English)

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4

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author name string

Michael Zhuo Wang

1

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3 January 2020

Judy Qiju Wu

2

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3 January 2020

Arlene S Bridges

3

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3 January 2020

Sally Kornbluth

5

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3 January 2020

Richard R Tidwell

6

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3 January 2020

James Edwin Hall

7

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Mary F Paine

8

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publication date

20 August 2007

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Drug Metabolism and Disposition

3 January 2020

published in

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volume

35

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issue

11

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page(s)

2067-2075

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Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

3 January 2020

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CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].

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Cloning of CYP2J2 gene and identification of functional polymorphisms

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20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat.

30 September 2017

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Alternative splicing determines the function of CYP4F3 by switching substrate specificity

30 September 2017

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cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine

30 September 2017

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Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors

30 September 2017

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Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11

30 September 2017

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30 September 2017

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Human trypanosomiasis in the Ivory Coast: therapy and problems

30 September 2017

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Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis

30 September 2017

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12 December 2020

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Identifiers

DOI

10.1124/DMD.107.016428

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3 January 2020

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3 January 2020

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