Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent (Q36621020)

15 August 2017

Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent (English)

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15 August 2017

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7

I J Stratford

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15 August 2017

1

L H Patterson

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15 August 2017

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S R McKeown

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15 August 2017

K Ruparelia

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15 August 2017

J A Double

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4

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15 August 2017

M C Bibby

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5

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15 August 2017

S Cole

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15 August 2017

language of work or name

English

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publication date

1 June 2000

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British Journal of Cancer

15 August 2017

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15 August 2017

82

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12

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15 August 2017

1984-1990

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https://scigraph.springernature.com/pub.10.1054/bjoc.2000.1163

15 August 2017

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cites work

Tirapazamine: laboratory data relevant to clinical activity.

1 reference

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Relationship of nm23 to proteolytic factors, proliferation and motility in breast cancer tissues and cell lines

30 September 2017

1 reference

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DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides

30 September 2017

1 reference

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Flow cytometric analysis and confocal imaging of anticancer alkylaminoanthraquinones and their N-oxides in intact human cells using 647-nm krypton laser excitation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363261

DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363261

The experimental development of bioreductive drugs and their role in cancer therapy.

30 September 2017

1 reference

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Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent

30 September 2017

1 reference

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Tumour hypoxia: the picture has changed in the 1990s

30 September 2017

1 reference

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Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).

30 September 2017

1 reference

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Bioreductive drugs and the selective induction of tumour hypoxia

30 September 2017

1 reference

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The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours

30 September 2017

1 reference

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Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia.

30 September 2017

1 reference

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Evidence for a therapeutic gain when AQ4N or tirapazamine is combined with radiation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2363261

AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo

28 June 2018

1 reference

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A new mouse tumor model system (RIF-1) for comparison of end-point studies

28 June 2018

1 reference

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The dynamics of tumor cords in an irradiated mouse mammary carcinoma with a large hypoxic cell component.

28 June 2018

1 reference

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Tests of Two Electron-Affinic Radiosensitizers in Vivo Using Regrowth of an Experimental Carcinoma

28 June 2018

1 reference

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Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide and AQ4N.

28 June 2018

1 reference

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Expression of xenobiotic metabolizing enzymes in breast cancer.

20 September 2018

1 reference

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Xenobiotic metabolising enzyme expression in colonic neoplasia

20 September 2018

1 reference

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Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug

20 September 2018

1 reference

12 December 2020

[Screening of principal enzymes involved in the metabolism of anticancer drugs in human and murine colonic tumors]

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12 December 2020

Reoxygenation and rehypoxiation in the SCCVII mouse tumor

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12 December 2020

Immunohistochemical localization of cytochrome P450 3A in human pulmonary carcinomas and normal bronchial tissue

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12 December 2020

Aliphatic amine N-oxides of DNA binding agents as bioreductive drugs

1 reference

12 December 2020

Vascular occlusion and tumour cell death

1 reference

12 December 2020

Characterization of a transplantable adenocarcinoma of the mouse colon producing cachexia in recipient animals

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12 December 2020

UKCCCR guidelines for the welfare of animals in experimental neoplasia

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12 December 2020

Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo

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12 December 2020

Bioreductive drugs into the next millennium

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12 December 2020

Enzymology of tirapazamine metabolism: a review

1 reference

12 December 2020

Identifiers

DOI

10.1054/BJOC.2000.1163

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Dimensions Publication ID

15 August 2017

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15 August 2017

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