Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin (Q36618010)

15 August 2017

Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin (English)

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15 August 2017

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5

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15 August 2017

M S Kovacs

1

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15 August 2017

D J Hocking

2

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15 August 2017

J W Evans

3

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15 August 2017

B G Siim

4

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15 August 2017

J M Brown

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15 August 2017

language of work or name

English

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publication date

1 June 1999

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British Journal of Cancer

15 August 2017

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15 August 2017

80

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15 August 2017

8

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15 August 2017

1245-1251

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https://scigraph.springernature.com/pub.10.1038/sj.bjc.6690492

15 August 2017

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cites work

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30 September 2017

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SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

30 September 2017

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The influence of microenvironmental factors during cancer therapy.

30 September 2017

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SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

30 September 2017

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The nucleoskeleton and the topology of transcription

30 September 2017

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Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors

30 September 2017

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DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells

30 September 2017

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Nucleotide excision repair genes as determinants of cellular sensitivity to cyclophosphamide analogs

30 September 2017

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Tissue oxygen distribution in head and neck cancer patients

30 September 2017

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Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial

28 June 2018

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Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells

28 June 2018

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Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia.

28 June 2018

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Biochemical and genetic analysis of the Chinese hamster mutants irs1 and irs2 and their comparison to cultured ataxia telangiectasia cells

28 June 2018

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Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

28 June 2018

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ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients

28 June 2018

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Nuclear Protein Matrix: Association with Newly Synthesized DNA

28 June 2018

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Tirapazamine is metabolized to its DNA-damaging radical by intranuclear enzymes.

28 June 2018

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Phase II study of the combination of the novel bioreductive agent, tirapazamine, with cisplatin in patients with advanced non-small-cell lung cancer.

20 September 2018

1 reference

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Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin.

20 September 2018

1 reference

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Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin.

20 September 2018

1 reference

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Direct measurement of the PO2 distribution in human malignant brain tumours.

20 September 2018

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Pretreatment oxygenation profiles of human soft tissue sarcomas

20 September 2018

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12 December 2020

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

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12 December 2020

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

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12 December 2020

Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine

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12 December 2020

Potentiation of cisplatin activity by the bioreductive agent tirapazamine

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12 December 2020

Tirapazamine with cisplatin in patients with advanced non-small-cell lung cancer: a phase II study

1 reference

12 December 2020

Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation

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12 December 2020

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

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12 December 2020

Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay

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12 December 2020

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements

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12 December 2020

Reoxygenation and rehypoxiation in the SCCVII mouse tumor

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12 December 2020

Measurement of Human Tumour Oxygenation Status by a Polarographic Needle Electrode: An analysis of inter- and intratumour heterogeneity

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6690492

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15 August 2017

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15 August 2017

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