Glutamine: a Trojan horse in ammonia neurotoxicity (Q36606140)

15 August 2017

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title

Glutamine: a Trojan horse in ammonia neurotoxicity (English)

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15 August 2017

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1

Jan Albrecht

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15 August 2017

Michael D Norenberg

2

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PubMed ID

17006913

15 August 2017

language of work or name

English

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publication date

1 October 2006

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15 August 2017

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15 August 2017

44

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15 August 2017

788-794

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15 August 2017

4

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The mitochondrial permeability transition.

15 August 2017

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Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy

21 January 2018

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Restoration of cerebrovascular CO2 responsivity by glutamine synthesis inhibition in hyperammonemic rats

21 January 2018

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Glutamine-dependent inhibition of pial arteriolar dilation to acetylcholine with and without hyperammonemia in the rat

21 January 2018

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Glutamine in the mechanism of ammonia-induced astrocyte swelling.

21 January 2018

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Swelling, acidosis, and irreversible damage of glial cells from exposure to arachidonic acid in vitro.

21 January 2018

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Biochemistry and physiology of brain ammonia

21 January 2018

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7 January 2021

Astrocytic-ammonia interactions in hepatic encephalopathy

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7 January 2021

Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome.

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7 January 2021

Pathophysiology of hepatic encephalopathy: a new look at ammonia

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7 January 2021

Astroglial dysfunction in hepatic encephalopathy

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7 January 2021

Hepatic encephalopathy: An update of pathophysiologic mechanisms

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7 January 2021

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.

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7 January 2021

Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication.

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7 January 2021

Sources of oxygen radicals in brain in acute ammonia intoxication in vivo

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7 January 2021

Oxidative and nitrosative stress in ammonia neurotoxicity

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7 January 2021

Oxidative stress in the pathogenesis of hepatic encephalopathy

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7 January 2021

Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy

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7 January 2021

Astrocyte swelling and protein tyrosine nitration in hepatic encephalopathy

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7 January 2021

The pathophysiology of brain edema in acute liver failure

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7 January 2021

Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis.

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7 January 2021

Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis.

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7 January 2021

The mitochondrial permeability transition

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7 January 2021

Mitochondrial permeability transitions: how many doors to the house?

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7 January 2021

Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes

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7 January 2021

Ammonia neurotoxicity: role of the mitochondrial permeability transition

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7 January 2021

Fine structural localization of glutamine synthetase in astrocytes of rat brain

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7 January 2021

Astrocyte metabolism of [15N]glutamine: implications for the glutamine-glutamate cycle

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7 January 2021

Cerebrospinal Fluid Glutamine as a Measure of Hepatic Encephalopathy

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7 January 2021

Amino acid, ammonia and neurotransmitter concentrations in hepatic encephalopathy: serial analysis in plasma and cerebrospinal fluid during treatment with an adapted amino acid solution.

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7 January 2021

Proton spectroscopy of brain glutamine in acute liver failure

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7 January 2021

Proton magnetic resonance spectroscopy of the brain in symptomatic and asymptomatic patients with liver cirrhosis.

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7 January 2021

Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.

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7 January 2021

Plasma and Brain Amino Acids in Fulminant Hepatic Failure and their Relationship to Hepatic Encephalopathy

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7 January 2021

Cerebral amino acid levels and uptake in rats after portocaval anastomosis: II. Regional studies in vivo

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7 January 2021

Amino acid changes in regions of the CNS in relation to function in experimental portal-systemic encephalopathy

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7 January 2021

Cerebral cortex ammonia and glutamine metabolism in two rat models of chronic liver insufficiency-induced hyperammonemia: influence of pair-feeding.

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7 January 2021

Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy.

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7 January 2021

Ionic basis for the depolarization of cerebral tissues by excitatory acidic amino acids

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7 January 2021

Exogenous glutamate is metabolized to glutamine and exported by rat primary astrocyte cultures.

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7 January 2021

THE INHIBITION IN VIVO OF CEREBRAL GLUTAMINE SYNTHETASE AND GLUTAMINE TRANSFERASE BY THE CONVULSANT METHIONINE SULFOXIMINE.

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7 January 2021

Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat

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7 January 2021

Effect of ammonia and methionine sulfoximine on myo-inositol transport in cultured astrocytes.

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7 January 2021

Effects of ammonia exposition on glioma cells: changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy

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7 January 2021

Methionine sulfoximine, a glutamine synthetase inhibitor, attenuates increased extracellular potassium activity during acute hyperammonemia

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7 January 2021

Ammonia-induced production of free radicals in primary cultures of rat astrocytes

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7 January 2021

Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia.

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7 January 2021

Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure

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7 January 2021

Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues

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7 January 2021

Ammonia stimulates glutamine uptake to the cerebral non-synaptic mitochondria of the rat.

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7 January 2021

Induction of the mitochondrial permeability transition in cultured astrocytes by glutamine

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7 January 2021

Glutamine-induced free radical production in cultured astrocytes

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7 January 2021

Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum.

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7 January 2021

Differential response of glutamine in cultured neurons and astrocytes

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7 January 2021

Phosphate activated glutaminase activity and glutamine uptake in primary cultures of astrocytes

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7 January 2021

Properties of phosphate activated glutaminase in astrocytes cultured from mouse brain

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7 January 2021

(1R,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid (RS-ACPD) reduces intracellular glutamate levels in astrocytes

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7 January 2021

Distribution of phosphate-activated glutaminase in the human cerebral cortex.

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7 January 2021

Identification of mitochondrial and non-mitochondrial glutaminase within select neurons and glia of rat forebrain by electron microscopic immunocytochemistry

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7 January 2021

Histochemistry of glutamate metabolizing enzymes in the rat cerebellar cortex

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7 January 2021

Isolation of astrocytes, neurons, and synaptosomes of rat brain cortex: distribution of enzymes of glutamate metabolism.

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7 January 2021

In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyric acid-glutamine cycling in rodent and human cortex: the central role of glutamine

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7 January 2021

Alpha-ketoglutaramate: increased concentrations in the cerebrospinal fluid of patients in hepatic coma.

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7 January 2021

Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain

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7 January 2021

Hyperammonemic encephalopathy

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7 January 2021

Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study

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7 January 2021

Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia

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7 January 2021

Mild hypothermia modifies ammonia-induced brain edema in rats after portacaval anastomosis.

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7 January 2021

Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

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7 January 2021

Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia

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7 January 2021

Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes.

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7 January 2021

Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices.

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7 January 2021

The role of arachidonic acid and oxygen radical metabolites in the pathogenesis of vasogenic brain edema and astrocytic swelling

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7 January 2021

Ascorbate inhibits edema in brain slices

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7 January 2021

Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress.

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7 January 2021

Effect of ascorbic acid on hyperoxic rat astrocytes

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7 January 2021

Gliotoxic action of glutamate on cultured astrocytes

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7 January 2021

Ammonia-induced astrocyte swelling in primary culture

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7 January 2021

Suppression of ammonia-induced astrocyte swelling by cyclosporin A.

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7 January 2021

The cellular hydration state: a critical determinant for cell death and survival

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7 January 2021

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7 January 2021

Primary astrocyte cultures?a key to astrocyte function

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7 January 2021

Identifiers

DOI

10.1002/HEP.21357

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15 August 2017

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PubMed ID

17006913