Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition. (Q36605942)

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8 March 2020

title

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition (English)

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8 March 2020

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10

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8 March 2020

8

Pann-Ghill Suh

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8 March 2020

6

Yong Ryoul Yang

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8 March 2020

1

Dohyun Park

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8 March 2020

2

Heeyoon Jeong

1 reference

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8 March 2020

4

Ara Koh

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8 March 2020

5

Ohman Kwon

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8 March 2020

7

Jungeun Noh

1 reference

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8 March 2020

author name string

Mi Nam Lee

series ordinal

3

1 reference

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8 March 2020

Hwangseo Park

series ordinal

9

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8 March 2020

language of work or name

English

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publication date

23 February 2016

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8 March 2020

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8 March 2020

volume

6

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8 March 2020

page(s)

21772

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Creative Commons Attribution 4.0 International

8 March 2020

copyright license

start time

1 February 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/srep21772

0 references

cites work

The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models

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Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

30 September 2017

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Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/β-catenin signaling pathway

30 September 2017

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mTOR: more targets of resveratrol?

30 September 2017

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mTOR kinase structure, mechanism and regulation

30 September 2017

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Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy

30 September 2017

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Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors

30 September 2017

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Autophagy modulation as a potential therapeutic target for diverse diseases

30 September 2017

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Resveratrol as a calorie restriction mimetic: therapeutic implications

30 September 2017

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mTOR signaling in growth control and disease

30 September 2017

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Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation

30 September 2017

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Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

30 September 2017

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Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

30 September 2017

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mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

30 September 2017

1 reference

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Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress.

30 September 2017

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SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.

30 September 2017

1 reference

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

30 September 2017

1 reference

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Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR

30 September 2017

1 reference

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Regulation of the autophagy protein LC3 by phosphorylation

30 September 2017

1 reference

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Termination of autophagy and reformation of lysosomes regulated by mTOR

30 September 2017

1 reference

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

30 September 2017

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Regulation of SIRT1 in cellular functions: role of polyphenols

30 September 2017

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

30 September 2017

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SIRT1 negatively regulates the mammalian target of rapamycin

30 September 2017

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

30 September 2017

1 reference

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

30 September 2017

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mTOR signaling at a glance

30 September 2017

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

30 September 2017

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Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK.

30 September 2017

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SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase

30 September 2017

1 reference

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Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

30 September 2017

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Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

30 September 2017

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Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

30 September 2017

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Resveratrol stimulates AMP kinase activity in neurons

30 September 2017

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Mechanism of human SIRT1 activation by resveratrol

30 September 2017

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Substrate-specific activation of sirtuins by resveratrol

30 September 2017

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763238

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763238

Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals

30 September 2017

1 reference

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Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763238

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763238

Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763238

Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

20 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSREP21772

Competitive and noncompetitive inhibition of the DNA-dependent protein kinase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26902888

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP21772

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26902888%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26902888%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26902888%20AND%20SRC:MED&resulttype=core&format=json