Huntingtin exon 1 fibrils feature an interdigitated β-hairpin-based polyglutamine core (Q36598899)

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6 March 2020

title

Huntingtin exon 1 fibrils feature an interdigitated β-hairpin-based polyglutamine core (English)

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6 March 2020

1

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6 March 2020

Karunakar Kar

3

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6 March 2020

Gábor Magyarfalvi

4

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6 March 2020

Jennifer C Boatz

6

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6 March 2020

Jozef Lewandowski

8

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6 March 2020

Patrick van der Wel

10

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6 March 2020

author name string

Hsiang-Kai Lin

2

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6 March 2020

Jonathan M Lamley

5

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6 March 2020

Abhishek Mandal

7

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6 March 2020

Ronald Wetzel

9

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6 March 2020

language of work or name

English

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publication date

1 February 2016

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Proceedings of the National Academy of Sciences of the United States of America

6 March 2020

published in

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volume

113

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6 March 2020

issue

6

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6 March 2020

page(s)

1546-1551

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Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease.

6 March 2020

cites work

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Super-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregates

30 September 2017

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Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Simulation of the β- to α-sheet transition results in a twisted sheet for antiparallel and an α-nanotube for parallel strands: implications for amyloid formation

30 September 2017

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Structural complexity of a composite amyloid fibril

30 September 2017

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The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils

30 September 2017

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A compact beta model of huntingtin toxicity

30 September 2017

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Structural characterization of GNNQQNY amyloid fibrils by magic angle spinning NMR

30 September 2017

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TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

30 September 2017

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Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment

30 September 2017

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Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

30 September 2017

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Proton assisted recoupling and protein structure determination.

30 September 2017

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Quantum chemistry in parallel with PQS

30 September 2017

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3D structure determination of the Crh protein from highly ambiguous solid-state NMR restraints

30 September 2017

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Atomic structures of amyloid cross-beta spines reveal varied steric zippers

30 September 2017

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Solid-state NMR study of amyloid nanocrystals and fibrils formed by the peptide GNNQQNY from yeast prion protein Sup35p.

30 September 2017

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Characterization of a possible amyloidogenic precursor in glutamine-repeat neurodegenerative diseases

30 September 2017

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

30 September 2017

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30 September 2017

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Mutational analysis of the structural organization of polyglutamine aggregates

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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20 September 2018

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20 September 2018

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20 September 2018

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20 September 2018

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21 October 2018

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21 January 2018

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Measurement of Site-Specific13C Spin−Lattice Relaxation in a Crystalline Protein

21 October 2018

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21 January 2018

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Assessing polyglutamine conformation in the nucleating event by molecular dynamics simulations

21 January 2018

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PubMed

12 December 2020

Polyglutamine homopolymers having 8-45 residues form slablike beta-crystallite assemblies

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PubMed

12 December 2020

Kinetics and thermodynamics of amyloid assembly using a high-performance liquid chromatography-based sedimentation assay

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PubMed

12 December 2020

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1521933113

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6 March 2020

0 references

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6 March 2020

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