Cell-based models to study hepatic drug metabolism and enzyme induction in humans (Q36572634)

15 August 2017

1 reference

title

Cell-based models to study hepatic drug metabolism and enzyme induction in humans (English)

1 reference

15 August 2017

Marc Vermeir

1

1 reference

15 August 2017

Pieter Annaert

2

1 reference

15 August 2017

Rao N V S Mamidi

3

1 reference

15 August 2017

Dirk Roymans

4

1 reference

15 August 2017

Willem Meuldermans

5

1 reference

15 August 2017

Geert Mannens

6

1 reference

15 August 2017

language of work or name

English

0 references

publication date

1 June 2005

1 reference

Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

published in

1 reference

15 August 2017

volume

1

1 reference

15 August 2017

issue

1

1 reference

15 August 2017

page(s)

75-90

1 reference

Human drug metabolism and the cytochromes P450: application and relevance of in vitro models

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Interindividual variability in inhibition and induction of cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Present and future in vitro approaches for drug metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Human hepatocytes as a tool for studying toxicity and drug metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Cryopreservation of hepatocytes: a review of current methods for banking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Comparative effects of rifabutin and rifampicin on cytochromes P450 and UDP-glucuronosyl-transferases expression in fresh and cryopreserved human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

The expression of xenobiotic-metabolizing cytochromes P450 in fetal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Fetal hepatic drug elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Expression and induction of CYP3As in human fetal hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Human fetal liver cultures: basal activities and inducibility of epoxide hydrolases and aryl hydrocarbon hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Long-term culture of primary human hepatocytes with preservation of proliferative capacity and differentiated functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Metabolic pre-conditioning of cultured cells in physiological levels of insulin: generating resistance to the lipid-accumulating effects of plasma in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Requirement of 3D extracellular network for maintenance of mature hepatocyte morphology and suppression of alpha-fetoprotein synthesis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Novel approach for achieving double-layered cell sheets co-culture: overlaying endothelial cell sheets onto monolayer hepatocytes utilizing temperature-responsive culture dishes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Co-cultures of hepatocytes with epithelial-like cell lines: expression of drug-biotransformation activities by hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Drug metabolism in hepatocyte sandwich cultures of rats and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Extended primary culture of human hepatocytes in a collagen gel sandwich system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Phosphorylation of hepatocyte growth factor receptor and epidermal growth factor receptor of human hepatocytes can be maintained in a (3D) collagen sandwich culture system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Induction of cytochrome P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Characterization of testosterone metabolism and 7-hydroxycoumarin conjugation by rat and human liver slices after storage in liquid nitrogen for 1 h up to 6 months

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Novel strategies for immortalization of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Cultivation of immortalized human hepatocytes HepZ on macroporous CultiSpher G microcarriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Identification of in vitro protein biomarkers of idiosyncratic liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Immortalization of human hepatocytes by temperature-sensitive SV40 large-T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Possible applications of conditionally immortalized tissue cell lines with differentiation functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

A reversibly immortalized human hepatocyte cell line as a source of hepatocyte-based biological support

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Drug metabolism by Escherichia coli expressing human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Stable expression of human cytochrome P450 3A4 in V79 cells and its application for metabolic profiling of ergot derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expressi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Control and statistical analysis of in vitro reporter gene assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho-substituted polychlorinated biphenyls

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Expression of Cytochromes P-450 2E1, 3A4 and 1A1/1A2 in Growing and Confluent Human HepG2 Hepatoma Cells-Effect of Ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Phase I and II enzyme characterization of two sources of HepG2 cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Induction of CYP3A4 by 1alpha,25-dyhydroxyvitamin D3 in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Time-dependent transcriptional induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs by H+/K+ -ATPase inhibitors and other xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

The effects of mebendazole on P4501A activity in rat hepatocytes and HepG2 cells. Comparison with tiabendazole and omeprazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Hayflick, his limit, and cellular ageing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Generation of Hepatocyte-Like Cells from Human Embryonic Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Liver from bone marrow in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Bone marrow as a potential source of hepatic oval cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

In vitro hepatic differentiation of human mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Establishment of transgenic mice carrying human fetus-specific CYP3A7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Near completely humanized liver in mice shows human-type metabolic responses to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Expression of human cytochromes P450 in chimeric mice with humanized liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Cryopreservation of rat and human liver slices by rapid freezing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

Hepatocytes from non-hepatic adult stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.75

21 January 2018

Identifiers

DOI

10.1517/17425255.1.1.75

1 reference

15 August 2017

1 reference