Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors (Q36533318)

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scientific article published on 11 September 2015

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English	Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors	scientific article published on 11 September 2015

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23 February 2020

Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors (English)

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Bolette Hartmann

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Jens Juul Holst

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Mette M. Rosenkilde

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L S Hansen

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Kaare Christensen

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M Christensen

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Alexander H Sparre-Ulrich

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A H Sparre-Ulrich

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20 November 2015

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British Journal of Pharmacology

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Exaggerated glucagon-like peptide 1 response is important for improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes.

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International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors

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Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans

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Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide

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Characterization and biological actions of N-terminal truncated forms of glucose-dependent insulinotropic polypeptide.

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Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes

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Vaccination against GIP for the treatment of obesity

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Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

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Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.

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Biology of incretins: GLP-1 and GIP

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Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice.

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Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes.

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Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16).

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On the physiology of GIP and GLP-1.

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Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological increti

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Inhibition of gastric inhibitory polypeptide signaling prevents obesity

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Predominant role of GIP in the development of a metabolic syndrome-like phenotype in female Wistar rats submitted to forced catch-up growth.

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12 December 2020

based on heuristic

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Understanding interactions of gastric inhibitory polypeptide (GIP) with its G-protein coupled receptor through NMR and molecular modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/26359804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calculating receptor number from binding experiments using same compound as radioligand and competitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/26359804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C-terminus ends of secretin and VIP interact with the N-terminal domains of their receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26359804

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based on heuristic

inferred from PubMed ID database lookup

Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin rec

1 reference

https://pubmed.ncbi.nlm.nih.gov/26359804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.13323

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23 February 2020

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23 February 2020

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23 February 2020

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