DNA mismatch repair and Lynch syndrome (Q36527421)

14 August 2017

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title

DNA mismatch repair and Lynch syndrome (English)

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14 August 2017

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2

Stefan Zeuzem

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14 August 2017

Guido Plotz

1

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14 August 2017

Jochen Raedle

series ordinal

3

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14 August 2017

publication date

4 July 2006

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Journal of Molecular Histology

14 August 2017

published in

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14 August 2017

volume

37

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14 August 2017

issue

5-7

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14 August 2017

page(s)

271-283

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Lynch syndrome: history and current status

14 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS10735-006-9038-5

The mutH, mutL, mutS, and uvrD genes of Salmonella typhimurium LT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10735-006-9038-5

Mutations associated with HNPCC predisposition -- Update of ICG-HNPCC/INSiGHT mutation database

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10735-006-9038-5

Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10735-006-9038-5

Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication

21 January 2018

1 reference

12 December 2020

Identification and characterization of the mutL and mutS gene products of Salmonella typhimurium LT2.

1 reference

12 December 2020

Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase

1 reference

12 December 2020

Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis

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12 December 2020

Analysis of the quaternary structure of the MutL C-terminal domain

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12 December 2020

Mismatch recognition and DNA-dependent stimulation of the ATPase activity of hMutSalpha is abolished by a single mutation in the hMSH6 subunit.

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12 December 2020

Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair

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12 December 2020

Analysis of the human MutLalpha.MutSalpha complex

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12 December 2020

Screening for exonic copy number mutations at MSH2 and MLH1 by MAPH

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12 December 2020

DNA mismatch correction in a defined system

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12 December 2020

Molecular genetics and clinical-pathology features of hereditary nonpolyposis colorectal carcinoma (Lynch syndrome): historical journey from pedigree anecdote to molecular genetic confirmation

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12 December 2020

MSH2 genomic deletions are a frequent cause of HNPCC

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12 December 2020

Marker discrimination in transformation and mutation of pneumococcus

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12 December 2020

DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers

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12 December 2020

Bidirectional excision in methyl-directed mismatch repair

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12 December 2020

Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair

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12 December 2020

Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function

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12 December 2020

A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition

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12 December 2020

Mismatch repair gene PMS2: disease-causing germline mutations are frequent in patients whose tumors stain negative for PMS2 protein, but paralogous genes obscure mutation detection and interpretation

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12 December 2020

PCNA binding proteins

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12 December 2020

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

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12 December 2020

The DNA binding properties of the MutL protein isolated from Escherichia coli

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12 December 2020

Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria

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12 December 2020

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

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12 December 2020

Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system

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12 December 2020

Familial mutations in PMS2 can cause autosomal dominant hereditary nonpolyposis colorectal cancer

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12 December 2020

Analysis of interactions between mismatch repair initiation factors and the replication processivity factor PCNA

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12 December 2020

DNA mismatch repair: functions and mechanisms

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12 December 2020

Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD.

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12 December 2020

Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair

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12 December 2020

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

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12 December 2020

DNA mismatch repair: MutS structures bound to mismatches.

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12 December 2020

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse

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12 December 2020

Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli

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12 December 2020

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

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12 December 2020

Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs

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12 December 2020

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

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12 December 2020

MutS mediates heteroduplex loop formation by a translocation mechanism

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12 December 2020

The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin

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12 December 2020

Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair

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12 December 2020

The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair

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12 December 2020

Requirement for Phe36 for DNA binding and mismatch repair by Escherichia coli MutS protein

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12 December 2020

The alternating ATPase domains of MutS control DNA mismatch repair

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12 December 2020

Functional overlap in mismatch repair by human MSH3 and MSH6.

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12 December 2020

N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha

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12 December 2020

The interaction of DNA mismatch repair proteins with human exonuclease I

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12 December 2020

A defined human system that supports bidirectional mismatch-provoked excision

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12 December 2020

Mutations of GTBP in genetically unstable cells

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12 December 2020

Human mismatch repair: reconstitution of a nick-directed bidirectional reaction

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12 December 2020

The role of hPMS1 and hPMS2 in predisposing to colorectal cancer

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12 December 2020

Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair

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12 December 2020

Repair tracts in mismatched DNA heteroduplexes

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12 December 2020

Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability

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12 December 2020

Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.

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12 December 2020

ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

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12 December 2020

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

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12 December 2020

Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification

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12 December 2020

Escherichia coli MutL loads DNA helicase II onto DNA.

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12 December 2020

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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12 December 2020

Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer

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12 December 2020

Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability

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12 December 2020

Isolation and characterization of the Escherichia coli mutL gene product.

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12 December 2020

Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex

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12 December 2020

The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch

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12 December 2020

Microsatellite instability in cancer of the proximal colon

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12 December 2020

Slipped-strand mispairing: a major mechanism for DNA sequence evolution

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12 December 2020

Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants

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12 December 2020

DNA bending and unbending by MutS govern mismatch recognition and specificity

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12 December 2020

Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome).

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12 December 2020

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

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12 December 2020

EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer

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12 December 2020

Hereditary colorectal cancer

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12 December 2020

Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis

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12 December 2020

Mapping protein-protein interactions between MutL and MutH by cross-linking

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12 December 2020

PMS2 mutations in childhood cancer

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12 December 2020

hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.

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12 December 2020

The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer

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12 December 2020

BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors.

1 reference

12 December 2020

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

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12 December 2020

Methyl-directed mismatch repair is bidirectional

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12 December 2020

Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction

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12 December 2020

Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates

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12 December 2020

Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites

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12 December 2020

MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability

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12 December 2020

GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

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12 December 2020

Missense mutations in hMLH1 associated with colorectal cancer

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12 December 2020

Reconstitution of 5'-directed human mismatch repair in a purified system

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12 December 2020

Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism

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12 December 2020

Characterization of hMLH1 and hMSH2 gene dosage alterations in Lynch syndrome patients.

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12 December 2020

Genetic mapping of a locus predisposing to human colorectal cancer

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12 December 2020

DNA repair defects in colon cancer

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12 December 2020

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair

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12 December 2020

History of the International Collaborative Group on Hereditary Non Polyposis Colorectal Cancer.

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12 December 2020

Methyl-directed repair of DNA base-pair mismatches in vitro

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12 December 2020

Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes

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12 December 2020

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12 December 2020

Functional analysis of MLH1 mutations linked to hereditary nonpolyposis colon cancer

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12 December 2020

Novel PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndrome

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12 December 2020

Signaling from DNA mispairs to mismatch-repair excision sites despite intervening blockades

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12 December 2020

Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms

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12 December 2020

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

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12 December 2020

d(GATC) sequences influence Escherichia coli mismatch repair in a distance-dependent manner from positions both upstream and downstream of the mismatch

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12 December 2020

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

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12 December 2020

Founding mutations and Alu-mediated recombination in hereditary colon cancer

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12 December 2020

The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer

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12 December 2020

High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer

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12 December 2020

GHKL, an emergent ATPase/kinase superfamily

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12 December 2020

Hereditary nonpolyposis colorectal carcinoma (HNPCC) and HNPCC-like families: Problems in diagnosis, surveillance, and management

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12 December 2020

Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis

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12 December 2020

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

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12 December 2020

The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity

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12 December 2020

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines

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12 December 2020

Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.

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12 December 2020

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

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12 December 2020

Human MutSalpha specifically binds to DNA containing aminofluorene and acetylaminofluorene adducts.

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12 December 2020

Conversion of diploidy to haploidy

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12 December 2020

Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha

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12 December 2020

Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases

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12 December 2020

Binding of mismatched microsatellite DNA sequences by the human MSH2 protein

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12 December 2020

hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

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12 December 2020

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12 December 2020

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

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12 December 2020

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12 December 2020

Isolation and characterization of the Escherichia coli mutH gene product.

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12 December 2020

Heteroduplex repair in extracts of human HeLa cells

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12 December 2020

Mismatch repair assay

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12 December 2020

A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States

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12 December 2020

10.1007/S10735-006-9038-5

Identifiers

DOI

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14 August 2017

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