PKC-B inhibition: a new therapeutic approach for diabetic complications? (Q36518913)

14 August 2017

1 reference

title

PKC-B inhibition: a new therapeutic approach for diabetic complications? (English)

1 reference

14 August 2017

Avignon A

1

1 reference

PubMed ID

16799396

14 August 2017

Sultan A

series ordinal

2

1 reference

14 August 2017

1 June 2006

1 reference

14 August 2017

Diabetes and Metabolism

1 reference

14 August 2017

32

1 reference

14 August 2017

205-213

1 reference

14 August 2017

3

1 reference

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

14 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

The pathobiology of diabetic complications: a unifying mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Protein kinase C and the development of diabetic vascular complications

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

PKC-interacting proteins: from function to pharmacology

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

The role of protein kinase C in cell surface signal transduction and tumour promotion

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Atypical protein kinase C in insulin action and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

The potential role of PKC beta in diabetic retinopathy and macular edema

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Polyol pathway and protein kinase C activity of rat Schwannoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Vascular factors in diabetic neuropathy

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Hyperalgesia induced by peripheral inflammation is mediated by protein kinase C betaII isozyme in the rat spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Possible involvement of spinal protein kinase C in thermal allodynia and hyperalgesia in diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Hyperglycemia inhibits vascular smooth muscle cell apoptosis through a protein kinase C-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Selective inhibition of protein kinase Cbeta2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Protein kinase Cbeta inhibition attenuates osteopontin expression, macrophage recruitment, and tubulointerstitial injury in advanced experimental diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Effects of protein kinase Cbeta inhibition on neurovascular dysfunction in diabetic rats: interaction with oxidative stress and essential fatty acid dysmetabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized cl

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

Development and validity testing of the neuropathy total symptom score-6: questionnaire for the study of sensory symptoms of diabetic peripheral neuropathy

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

The effect of ruboxistaurin on nephropathy in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970270-7

7 January 2021

10.1016/S1262-3636(07)70270-7

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16799396