Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water (Q36518508)

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scientific article published on 17 December 2015

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English	Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water	scientific article published on 17 December 2015

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scholarly article

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3 March 2020

Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water (English)

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3 March 2020

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crystallography

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Eduardo Hilario

1

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3 March 2020

Leonard J Mueller

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3 March 2020

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Bethany G Caulkins

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3 March 2020

Yu-Ming M Huang

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3 March 2020

Wanli You

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3 March 2020

Chia-En A Chang

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3 March 2020

Michael F Dunn

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3 March 2020

Li Fan

8

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3 March 2020

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17 December 2015

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3 March 2020

Biochimica et Biophysica Acta

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3 March 2020

1864

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3 March 2020

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3 March 2020

268-279

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3 March 2020

Protonation states and catalysis: Molecular dynamics studies of intermediates in tryptophan synthase

1 reference

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Hydrophobic gating in ion channels

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Allostery and Substrate Channeling in the Tryptophan Synthase Bienzyme Complex: Evidence for Two Subunit Conformations and Four Quaternary States

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Linking Crystallographic Model and Data Quality

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30 September 2017

Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex

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REFMAC5 for the refinement of macromolecular crystal structures

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The role of oligomerization and cooperative regulation in protein function: the case of tryptophan synthase

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Molecular replacement with MOLREP

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Tryptophan synthase: the workings of a channeling nanomachine

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30 September 2017

Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands

1 reference

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30 September 2017

Synthesis and characterization of allosteric probes of substrate channeling in the tryptophan synthase bienzyme complex

1 reference

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30 September 2017

ON THE SEPARATION OF THE TRYPTOPHAN SYNTHETASE OF ESCHERICHIA COLI INTO TWO PROTEIN COMPONENTS

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30 September 2017

Indole and Serine in the Biosynthesis and Breakdown of Tryptophane

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

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Scaling and assessment of data quality

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Structural elements in IGP synthase exclude water to optimize ammonia transfer.

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Coot: model-building tools for molecular graphics

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30 September 2017

Enzymes with molecular tunnels

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30 September 2017

Developing an energy landscape for the novel function of a (beta/alpha)8 barrel: ammonia conduction through HisF.

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30 September 2017

Structural basis for the impaired channeling and allosteric inter-subunit communication in the beta A169L/beta C170W mutant of tryptophan synthase

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30 September 2017

The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia

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30 September 2017

The molecular basis of substrate channeling

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Carbamoyl phosphate synthetase: a tunnel runs through it

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30 September 2017

Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes

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30 September 2017

Ligand-mediated changes in the tryptophan synthase indole tunnel probed by nile red fluorescence with wild type, mutant, and chemically modified enzymes

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.

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Mechanism of mutual activation of the tryptophan synthase alpha and beta subunits. Analysis of the reaction specificity and substrate-induced inactivation of active site and tunnel mutants of the beta subunit

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30 September 2017

Serine modulates substrate channeling in tryptophan synthase. A novel intersubunit triggering mechanism

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30 September 2017

Evidence that mutations in a loop region of the alpha-subunit inhibit the transition from an open to a closed conformation in the tryptophan synthase bienzyme complex

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Protein architecture, dynamics and allostery in tryptophan synthase channeling

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Tryptophan synthase: structure and function of the monovalent cation site

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Cooperative fluctuations and subunit communication in tryptophan synthase

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Inhibition of tryptophan synthase by (1-fluorovinyl)glycine.

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Allosteric linkages between beta-site covalent transformations and alpha-site activation and deactivation in the tryptophan synthase bienzyme complex

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A Steady-State Kinetic Investigation of the Reaction Mechanism of the Tryptophan Synthetase of Escherichia coli

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Characterization of the reaction of L-serine and indole with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy.

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The tryptophan synthase bienzyme complex transfers indole between the alpha- and beta-sites via a 25-30 A long tunnel

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Mechanism of the physiological reaction catalyzed by tryptophan synthase from Escherichia coli.

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Allosteric interactions coordinate catalytic activity between successive metabolic enzymes in the tryptophan synthase bienzyme complex

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Determination of protein: A modification of the lowry method that gives a linear photometric response

1 reference

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12 December 2020

based on heuristic

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Studies on the mechanism of the tryptophan synthetase reaction

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https://pubmed.ncbi.nlm.nih.gov/26708480

12 December 2020

based on heuristic

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The exclusion of free indole as an intermediate in the biosynthesis of tryptophan in Neurospora crassa

1 reference

https://pubmed.ncbi.nlm.nih.gov/26708480

12 December 2020

based on heuristic

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10.1016/J.BBAPAP.2015.12.006

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3 March 2020

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3 March 2020

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3 March 2020

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