Disruption of the p53-Mdm2 complex by Nutlin-3 reveals different cancer cell phenotypes (Q36503039)

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11 January 2020

title

Disruption of the p53-Mdm2 complex by Nutlin-3 reveals different cancer cell phenotypes (English)

1 reference

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11 January 2020

author name string

Nicoleta C Arva

1

1 reference

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11 January 2020

Kathryn E Talbott

2

1 reference

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11 January 2020

Danielle R Okoro

3

1 reference

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11 January 2020

Angelika Brekman

4

1 reference

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11 January 2020

Wei Gang Qiu

5

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11 January 2020

Jill Bargonetti

6

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11 January 2020

publication date

1 January 2008

1 reference

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11 January 2020

published in

Ethnicity and Disease

1 reference

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11 January 2020

volume

18

1 reference

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11 January 2020

issue

2 Suppl 2

1 reference

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11 January 2020

page(s)

S2-1-8

1 reference

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

11 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

Strange bedfellows: polyadenylation factors at the promoter

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

Multiple roles of the tumor suppressor p53.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

MDM2 SNP309 Accelerates Tumor Formation in a Gender-Specific and Hormone-Dependent Manner

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535287

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18646312

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Analysis of the molecular species generated by mdm2 gene amplification in liposarcomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18646312

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

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11 January 2020

1 reference