To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5. (Q36501920)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17188855%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

review article

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title

To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5 (English)

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23 December 2019

1

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23 December 2019

author name string

Susan P Gilbert

series ordinal

2

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23 December 2019

language of work or name

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26 December 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17188855%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Cell Biology

23 December 2019

published in

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23 December 2019

volume

19

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23 December 2019

issue

1

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23 December 2019

page(s)

75-81

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Kinesin motor mechanics: binding, stepping, tracking, gating, and limping

23 December 2019

cites work

1 reference

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Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis

30 September 2017

1 reference

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Allosteric inhibition of kinesin-5 modulates its processive directional motility.

30 September 2017

1 reference

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Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain

30 September 2017

1 reference

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A structural model for monastrol inhibition of dimeric kinesin Eg5.

30 September 2017

1 reference

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Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro

30 September 2017

1 reference

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30 September 2017

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The tethered motor domain of a kinesin-microtubule complex catalyzes reversible synthesis of bound ATP.

30 September 2017

1 reference

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Alternating site ATPase pathway of rat conventional kinesin

30 September 2017

1 reference

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Analysis of the kinesin superfamily: insights into structure and function

30 September 2017

1 reference

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The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Kinesin: walking, crawling or sliding along?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Kinesin: world's tiniest biped

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

The kinetic mechanism of kinesin.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

30 September 2017

Kinesin's second step

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

What kinesin does at roadblocks: the coordination mechanism for molecular walking

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Kinesin walks hand-over-hand

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Inhibition of a mitotic motor protein: where, how, and conformational consequences

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

A kinesin switch I arginine to lysine mutation rescues microtubule function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Nucleotide-induced conformations in the neck region of dimeric kinesin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Probing the kinesin reaction cycle with a 2D optical force clamp

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Kinesin-microtubule binding depends on both nucleotide state and loading direction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

A structural change in the kinesin motor protein that drives motility

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Kinesin's processivity results from mechanical and chemical coordination between the ATP hydrolysis cycles of the two motor domains.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Kinesin hydrolyses one ATP per 8-nm step

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Purification and characterization of two monomeric kinesin constructs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Fluctuation analysis of motor protein movement and single enzyme kinetics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Kinesin ATPase: rate-limiting ADP release

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Bead movement by single kinesin molecules studied with optical tweezers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Single-molecule observations of neck linker conformational changes in the kinesin motor protein.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Stepping and stretching. How kinesin uses internal strain to walk processively

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Coupled chemical and mechanical reaction steps in a processive Neurospora kinesin

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Coupling of kinesin steps to ATP hydrolysis.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Pre-steady-state kinetics of the microtubule-kinesin ATPase.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Docking and rolling, a model of how the mitotic motor Eg5 works

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Mechanics of the kinesin step.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Kinesin moves by an asymmetric hand-over-hand mechanism

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Configuration of the two kinesin motor domains during ATP hydrolysis

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Motor domain mutation traps kinesin as a microtubule rigor complex

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Measuring kinesin's first step

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

ATP reorients the neck linker of kinesin in two sequential steps

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Alternating site mechanism of the kinesin ATPase.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Kinetic mechanism of a monomeric kinesin construct.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Movement of microtubules by single kinesin molecules

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2270473

Interacting head mechanism of microtubule-kinesin ATPase

21 September 2018

1 reference

12 December 2020

Feedback of the kinesin-1 neck-linker position on the catalytic site

1 reference

12 December 2020

Nucleotide binding and hydrolysis induces a disorder-order transition in the kinesin neck-linker region

1 reference

12 December 2020

Homotetrameric form of Cin8p, a Saccharomyces cerevisiae kinesin-5 motor, is essential for its in vivo function

1 reference

12 December 2020

Alternate fast and slow stepping of a heterodimeric kinesin molecule

1 reference

12 December 2020

10.1016/J.CEB.2006.12.011

Identifiers

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23 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17188855%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

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