Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment (Q36484933)

14 August 2017

Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment (English)

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14 August 2017

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Douglas G Tilley

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PubMed ID

16716102

14 August 2017

Howard A Rockman

series ordinal

2

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14 August 2017

1 May 2006

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Expert Review of Cardiovascular Therapy

14 August 2017

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14 August 2017

4

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14 August 2017

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14 August 2017

417-432

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Tackling the EGFR in pathological tissue remodelling

14 August 2017

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Seven-transmembrane-spanning receptors and heart function

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Cardiac hypertrophy: role of G protein-coupled receptors

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Altered cAMP-mediated signalling and its role in the pathogenesis of dilated cardiomyopathy

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Calcium signaling in cardiac ventricular myocytes.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Desensitization of G protein-coupled receptors and neuronal functions

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Ontogenesis of beta-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Transduction of receptor signals by beta-arrestins

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The cardiac beta2-adrenergic signalling a new role for the cPLA2.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

beta(2)-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The cytosolic phospholipase A2 pathway, a safeguard of beta2-adrenergic cardiac effects in rat.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Molecular restoration of beta-adrenergic receptor signaling improves contractile function of failing hearts

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Upregulation of functional beta(3)-adrenergic receptor in the failing canine myocardium

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Network integration of the adrenergic system in cardiac hypertrophy

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Pharmacology and physiology of human adrenergic receptor polymorphisms

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Cardiovascular drug class specificity: beta-blockers

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Cardiac Gsalpha overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

G-protein-coupled receptor kinase activity in human heart failure: effects of beta-adrenoceptor blockade

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Matrix metalloproteinase-dependent EGF receptor activation in hypertension and left ventricular hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Signalling by PI3K isoforms: insights from gene-targeted mice.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Role of phosphoinositide 3-kinase in cardiac function and heart failure

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

21 January 2018

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https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

21 January 2018

Identifiers

DOI

10.1586/14779072.4.3.417

1 reference

14 August 2017

1 reference

PubMed ID

16716102