Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. (Q36476486)

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English	Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis.	scientific article

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26 December 2019

Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis (English)

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26 December 2019

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Andrzej Slominski

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26 December 2019

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26 December 2019

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Karine Rousseau

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26 December 2019

Sobia Kauser

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26 December 2019

Lynn E Pritchard

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26 December 2019

Anne Warhurst

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26 December 2019

Robert L Oliver

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26 December 2019

Edward T Wei

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26 December 2019

Anthony J Thody

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26 December 2019

Desmond J Tobin

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26 December 2019

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22 February 2007

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26 December 2019

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26 December 2019

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26 December 2019

8

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26 December 2019

1844-1856

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26 December 2019

Corticotropin releasing hormone and the skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Agouti-related protein (83-132) is a competitive antagonist at the human melanocortin-4 receptor: no evidence for differential interactions with pro-opiomelanocortin-derived ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Differential expression of a cutaneous corticotropin-releasing hormone system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Characterization of a serine protease that cleaves pro-gamma-melanotropin at the adrenal to stimulate growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Analysis of constitutive and constitutive-like secretion in semi-intact pituitary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

D-amino acid-substituted analogs of corticotropin-releasing hormone (CRH) and urocortin with selective agonist activity at CRH1 and CRH2beta receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

On the potential role of proopiomelanocortin in skin physiology and pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Proopiomelanocortin production by epidermal cells: evidence for an immune neuroendocrine network in the epidermis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Corticotropin, lipotropin, and beta-endorphin production by a human nonpituitary tumor in culture: evidence for a common precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

30 September 2017

Expression of proopiomelanocortin (POMC)-derived melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) peptides in skin of basal cell carcinoma patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

28 June 2018

ACTH precursors: biological significance and clinical relevance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

28 June 2018

Alpha-melanocyte stimulating hormone and its analogue Nle4DPhe7 alpha-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

28 June 2018

Differential release of proopiomelanocortin-derived peptides from the human pituitary: evidence from a panel of two-site immunoradiometric assays.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

28 June 2018

Elevated levels of adrenocorticotropin (ACTH) precursors in post-adrenalectomy Cushing's disease and their regulation by glucocorticoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

28 June 2018

Cerebrospinal fluid levels of beta endorphin in painful and painless diabetic polyneuropathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

28 June 2018

Direct measurement of the precursors of adrenocorticotropin in human plasma by two-site immunoradiometric assay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

28 June 2018

Small cell lung cancer cell lines secrete predominantly ACTH precursor peptides not ACTH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

28 June 2018

Melanotropic activity of gamma MSH peptides in melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

28 June 2018

Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulating hormone in human dermal papilla cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

CRH stimulates POMC activity and corticosterone production in dermal fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

A fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

beta-Endorphin as a regulator of human hair follicle melanocyte biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

Effect of alpha- and betamelanocyte stimulating hormones on the skin colour of man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

Regulation of human epidermal melanocyte biology by beta-endorphin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: evidence that secretion is regulated with respect to energy balance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

Human dermal fibroblasts express prohormone convertases 1 and 2 and produce proopiomelanocortin-derived peptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

Retinoic acid regulates oral epithelial differentiation by two mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

Pro-opiomelanocortin gene expression and peptide secretion in human small-cell lung cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

21 September 2018

Pro-opiomelanocortin-Related Peptides, Prohormone Convertases 1 and 2 and the Regulatory Peptide 7B2 are Present in Melanosomes of Human Melanocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2253185

4 December 2018

Spatiotemporal expression, distribution, and processing of POMC and POMC-derived peptides in murine skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MSH peptides are present in mammalian skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical evaluation of a two-site immunoradiometric assay for adrenocorticotrophin in unextracted human plasma using monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ACTH stimulates melanogenesis in cultured human melanocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human melanocyte stimulating hormone receptor has evolved to become "super-sensitive" to melanocortin peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and long-term culture of human hair-follicle melanocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular matrix derived from hair and skin fibroblasts stimulates human skin melanocyte tyrosinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proopiomelanocortin gene product regulation in keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eumelanin and Phaeomelanin Contents of Human Epidermis and Cultured Melanocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterisation of ACTH Peptides in Human Skin and Their Activation of the Melanocortin-1 Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of corticotropin-releasing hormone (CRH) in human skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does alpha-MSH have a role in regulating skin pigmentation in humans?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated levels of adrenocorticotropin (ACTH) precursors in post-adrenalectomy Cushing's disease and their regulation by glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/17317724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1096/FJ.06-7398COM

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17317724%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17317724%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17317724%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

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