Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration (Q36474012)

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English	Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration	scientific article

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scholarly article

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28 February 2020

Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration (English)

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28 February 2020

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Jau-Shyong Hong

3

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28 February 2020

author name string

Shih-Heng Chen

1

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28 February 2020

Esteban A Oyarzabal

2

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publication date

26 October 2015

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28 February 2020

Current Opinion in Pharmacology

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28 February 2020

26

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28 February 2020

54-60

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28 February 2020

The dynamics of monocytes and microglia in Alzheimer's disease

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30 September 2017

α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation

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30 September 2017

Neuroinflammation in Alzheimer's disease

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30 September 2017

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models

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Ligand recognition specificity of leukocyte integrin αMβ2 (Mac-1, CD11b/CD18) and its functional consequences

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A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit

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30 September 2017

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30 September 2017

Reactive gliosis and the multicellular response to CNS damage and disease.

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30 September 2017

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30 September 2017

New insights on NOX enzymes in the central nervous system

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30 September 2017

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

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30 September 2017

The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function

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30 September 2017

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

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30 September 2017

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

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30 September 2017

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30 September 2017

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

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30 September 2017

The neuroprotective effects of apocynin

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30 September 2017

TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

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30 September 2017

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30 September 2017

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30 September 2017

β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway

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30 September 2017

HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.

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30 September 2017

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30 September 2017

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

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30 September 2017

DAMPening inflammation by modulating TLR signalling

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30 September 2017

Does neuroinflammation fan the flame in neurodegenerative diseases?

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30 September 2017

Immune activation in brain aging and neurodegeneration: too much or too little?

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30 September 2017

Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease

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30 September 2017

Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury

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30 September 2017

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30 September 2017

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.

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30 September 2017

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

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30 September 2017

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

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30 September 2017

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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30 September 2017

HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.

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Negative regulation of toll-like receptor-mediated immune responses

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30 September 2017

Microglia and Macrophage Activation and the Regulation of Complement-Receptor-3 (CR3/MAC-1)-Mediated Myelin Phagocytosis in Injury and Disease

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NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation.

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Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotection

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21 September 2018

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21 September 2018

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21 September 2018

Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.

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21 September 2018

Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study

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21 September 2018

Role of the cytoskeleton in rapid activation of CD11b/CD18 function and its subsequent downregulation in neutrophils.

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21 September 2018

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21 October 2018

MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-[9H-(2,7-dimethylfluorenyl-9-methoxy)carbonyl]-L-leucine, NPC 15669, prevents neutrophil adherence to endothelium and inhibits CD11b/CD18 upregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26498406

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.COPH.2015.10.001

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Europe PubMed Central

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28 February 2020

1 reference

Europe PubMed Central

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28 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26498406%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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