Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. (Q36470463)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18292815%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5 (English)

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3 January 2020

7

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3 January 2020

author name string

Fulu Liu

1

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3 January 2020

Ghada Kunter

2

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3 January 2020

Maxwell M Krem

3

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3 January 2020

William C Eades

4

1 reference

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3 January 2020

Jennifer A Cain

5

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3 January 2020

Michael H Tomasson

6

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3 January 2020

Daniel C Link

8

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3 January 2020

language of work or name

English

0 references

publication date

1 March 2008

1 reference

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Journal of Clinical Investigation

3 January 2020

published in

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3 January 2020

volume

118

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3 January 2020

issue

3

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3 January 2020

page(s)

946-955

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STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output

3 January 2020

cites work

1 reference

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Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.

30 September 2017

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Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

30 September 2017

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Severe congenital neutropenia

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30 September 2017

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The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy

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30 September 2017

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30 September 2017

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30 September 2017

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NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal

30 September 2017

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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

30 September 2017

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Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

30 September 2017

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Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation

30 September 2017

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Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells

30 September 2017

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Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation

30 September 2017

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Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

30 September 2017

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

30 September 2017

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Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene

30 September 2017

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Single cell profiling of potentiated phospho-protein networks in cancer cells.

30 September 2017

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Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

30 September 2017

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Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5.

30 September 2017

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Infantile genetic agranulocytosis; agranulocytosis infantilis hereditaria

30 September 2017

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Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma

30 September 2017

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

30 September 2017

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

30 September 2017

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Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.

30 September 2017

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SOCS proteins: negative regulators of cytokine signaling

30 September 2017

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STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation

30 September 2017

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Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G(2)/M transit and do not reenter G(0).

30 September 2017

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Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

30 September 2017

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Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival.

30 September 2017

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Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene.

30 September 2017

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Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia

30 September 2017

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Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia.

30 September 2017

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

30 September 2017

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A randomized controlled phase III trial of recombinant human granulocyte colony-stimulating factor (filgrastim) for treatment of severe chronic neutropenia.

30 September 2017

1 reference

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Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia

30 September 2017

1 reference

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The kinetics of clonal dominance in myeloproliferative disorders

30 September 2017

1 reference

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Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway

28 June 2018

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Specific signals generated by the cytoplasmic domain of the granulocyte colony-stimulating factor (G-CSF) receptor are not required for G-CSF-dependent granulocytic differentiation.

28 June 2018

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Rarity of dominant-negative mutations of the G-CSF receptor in patients with blast crisis of chronic myeloid leukemia or de novo acute leukemia.

28 June 2018

1 reference

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Granulocyte colony-stimulating factor (G-CSF) production and G-CSF receptor structure in patients with congenital neutropenia

28 June 2018

1 reference

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STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells.

28 June 2018

1 reference

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Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey.

21 September 2018

1 reference

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Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.

21 September 2018

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The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells

21 September 2018

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Comparative analyses of sheep and human TRG joining regions: evolution of J genes in Bovidae is driven by sequence conservation in their promoters for germline transcription.

21 September 2018

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Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

21 September 2018

1 reference

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Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. Experience of the French Severe Chronic Neutropenia Study Group

21 September 2018

1 reference

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Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

21 September 2018

1 reference

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In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

21 September 2018

1 reference

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Dysregulated expression of COOH-terminally truncated Stat5 and loss of IL2-inducible Stat5-dependent gene expression in Sezary Syndrome

21 September 2018

1 reference

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HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

21 September 2018

1 reference

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Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2248325

Stat5 tetramer formation is associated with leukemogenesis

21 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2248325

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

4 December 2018

1 reference

12 December 2020

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

12 December 2020

Spontaneous remission of granulocyte colony-stimulating factor-associated leukemia in a child with severe congenital neutropenia

1 reference

12 December 2020

Analysis of granulocyte colony stimulating factor receptor isoforms, polymorphisms and mutations in normal haemopoietic cells and acute myeloid leukaemia blasts

1 reference

12 December 2020

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

1 reference

12 December 2020

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

1 reference

12 December 2020

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI32704

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18292815%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18292815%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference