6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors (Q36467564)

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English	6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors	scientific article

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23 February 2020

6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors (English)

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23 February 2020

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Sudhir Raghavan

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23 February 2020

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Lei Wang

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Adrianne Wallace

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Siobhan M Deis

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Mike R Wilson

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Si Yang

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Lisa Polin

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Kathryn White

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Juiwanna Kushner

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Steven Orr

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Christina George

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Carrie O'Connor

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Zhanjun Hou

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Shermaine Mitchell-Ryan

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Charles E Dann

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Larry H Matherly

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Aleem Gangjee

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28 August 2015

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23 February 2020

Journal of Medicinal Chemistry

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23 February 2020

6938-6959

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23 February 2020

Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter

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Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate trans

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10.1021/ACS.JMEDCHEM.5B00801

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23 February 2020

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23 February 2020

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23 February 2020

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