Progress in identifying peptides and small-molecule inhibitors targeted to gp41 of HIV-1. (Q36458359)

14 August 2017

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title

Progress in identifying peptides and small-molecule inhibitors targeted to gp41 of HIV-1. (English)

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14 August 2017

1

Asim K Debnath

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14 August 2017

language of work or name

English

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publication date

1 May 2006

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Expert Opinion on Investigational Drugs

14 August 2017

published in

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14 August 2017

volume

15

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14 August 2017

issue

5

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14 August 2017

page(s)

465-478

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The discovery of HIV as the cause of AIDS.

14 August 2017

cites work

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New advances in HIV entry inhibitors development

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High throughput screening and characterization of HIV-1 entry inhibitors targeting gp41: theories and techniques

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HIV-1 gp41 as a target for viral entry inhibition

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Virus entry as a target for anti-HIV intervention

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Peptide and non-peptide HIV fusion inhibitors

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Mechanisms of viral membrane fusion and its inhibition

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A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition

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Propensity for a leucine zipper-like domain of human immunodeficiency virus type 1 gp41 to form oligomers correlates with a role in virus-induced fusion rather than assembly of the glycoprotein complex

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HIV-1 inhibition by a peptide

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Inhibition of HIV-1 infection by a fusion domain binding peptide from the HIV-1 envelope glycoprotein GP41

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A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion

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Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

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The safety, plasma pharmacokinetics, and antiviral activity of subcutaneous enfuvirtide (T-20), a peptide inhibitor of gp41-mediated virus fusion, in HIV-infected adults.

21 January 2018

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Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion

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Anti-human immunodeficiency virus interactions of SCH-C (SCH 351125), a CCR5 antagonist, with other antiretroviral agents in vitro

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A trimeric structural domain of the HIV-1 transmembrane glycoprotein.

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Atomic structure of a thermostable subdomain of HIV-1 gp41

21 January 2018

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Helical interactions in the HIV-1 gp41 core reveal structural basis for the inhibitory activity of gp41 peptides

21 January 2018

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Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

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Functional inactivation of genes by dominant negative mutations

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Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells

21 January 2018

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Differential inhibition of HIV-1 and SIV envelope-mediated cell fusion by C34 peptides derived from the C-terminal heptad repeat of gp41 from diverse strains of HIV-1, HIV-2, and SIV.

21 January 2018

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Short constrained peptides that inhibit HIV-1 entry

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Inhibition of HIV type 1 infectivity by constrained alpha-helical peptides: implications for the viral fusion mechanism

21 January 2018

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Design of a peptide inhibitor that blocks the cell fusion mediated by glycoprotein 41 of human immunodeficiency virus type 1.

21 January 2018

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Stronger anti-HIV-1 activity of C-peptide derived from HIV-1 89.6 gp41 C-terminal heptad repeated sequence

21 January 2018

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Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region

21 January 2018

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Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues

21 January 2018

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Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection

21 January 2018

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Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41.

21 January 2018

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Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion.

21 January 2018

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Protein design of an HIV-1 entry inhibitor

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21 January 2018

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Core structure of gp41 from the HIV envelope glycoprotein

21 January 2018

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Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket

21 January 2018

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Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements

21 January 2018

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The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core

21 January 2018

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A salt bridge between an N-terminal coiled coil of gp41 and an antiviral agent targeted to the gp41 core is important for anti-HIV-1 activity

21 January 2018

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N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion

21 January 2018

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Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion

21 January 2018

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Structure-based identification of small molecule antiviral compounds targeted to the gp41 core structure of the human immunodeficiency virus type 1

21 January 2018

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A screening assay for antiviral compounds targeted to the HIV-1 gp41 core structure using a conformation-specific monoclonal antibody

21 January 2018

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Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

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XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41.

21 January 2018

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Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41

21 January 2018

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New developments in anti-HIV chemotherapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.15.5.465

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.15.5.465

A trimeric structural subdomain of the HIV-1 transmembrane glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.15.5.465

An isoleucine zipper peptide forms a native-like triple stranded coiled coil in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.5.465

10.1517/13543784.15.5.465

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference