New genes in inflammatory bowel disease: lessons for complex diseases? (Q36456702)

14 August 2017

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title

New genes in inflammatory bowel disease: lessons for complex diseases? (English)

1 reference

inflammatory bowel diseases

14 August 2017

0 references

0 references

4

Jack Satsangi

1 reference

14 August 2017

Daniel R Gaya

1

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14 August 2017

Richard K Russell

series ordinal

2

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14 August 2017

Elaine R Nimmo

series ordinal

3

1 reference

14 August 2017

language of work or name

English

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publication date

1 April 2006

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14 August 2017

14

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inferred from page(s)

published in

The Lancet

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14 August 2017

367

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14 August 2017

1271-1284

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14 August 2017

9518

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Incidence of Crohn's disease in Stockholm County 1955-1989.

14 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genetics versus environment in inflammatory bowel disease: results of a British twin study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

1 reference

7 January 2021

Review article: the genetics of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Prevalence of Inflammatory Bowel Disease among Relatives of Patients with Crohn's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Prevalence and family risk of ulcerative colitis and Crohn's disease: an epidemiological study among Europeans and south Asians in Leicestershire

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Familial occurrence of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Familial aggregation in Crohn's disease: increased age-adjusted risk and concordance in clinical characteristics.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Familial Crohn's disease in single or multiple first-degree relatives.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Clinical patterns of familial inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Crohn's disease: influence of age at diagnosis on site and clinical type of disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Inflammatory bowel disease and the X chromosome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genetic defects and clinical characteristics of patients with a form of oculocutaneous albinism (Hermansky-Pudlak syndrome)

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The Human Genome Project: from mapping to sequencing

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Clinical relevance of advances in genetics and pharmacogenetics of IBD.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Linkage of inflammatory bowel disease to human chromosome 6p

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Mapping of a susceptibility locus for Crohn's disease on chromosome 16

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Lack of common NOD2 variants in Japanese patients with Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association of NOD2 with Crohn's Disease in a homogenous Irish population

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Subclinical intestinal inflammation: an inherited abnormality in Crohn’s disease relatives?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

CARD15 mutations are rare in Swedish pediatric Crohn disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The molecular classification of the clinical manifestations of Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Mutations in the NOD2/CARD15 gene in Crohn's disease are associated with ileocecal resection and are a risk factor for reoperation.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease: is Hungary different?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Variants of CARD15 are Associated with an Aggressive Clinical Course of Crohn's Disease-An IG-IBD Study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Card15 and Crohn's disease: healthy homozygous carriers of the 3020insC frameshift mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Prevalence of mutations of the NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

3020insC mutation within the NOD2 gene in Crohn's disease: frequency and association with clinical pattern in an Italian population

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The c-insertion mutation of the NOD2 gene is associated with fistulizing and fibrostenotic phenotypes in Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

CARD15 genotype and phenotype analysis in 55 pediatric patients with Crohn disease from Saxony, Germany

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Long-term evolution of disease behavior of Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Response to infliximab treatment in Crohn's disease is not associated with mutations in the CARD15 (NOD2) gene: an analysis in 534 patients from two multicenter, prospective GCP-level trials

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NOD2/CARD15 does not influence response to infliximab in Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

CARD15 mutations in Blau syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Human Nod1 confers responsiveness to bacterial lipopolysaccharides

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Crohn's disease and the NOD2 gene: a role for paneth cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Epithelial antimicrobial peptides: innate local host response elements

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Reduced Paneth cell alpha-defensins in ileal Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Inflammatory Bowel Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in h

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NOD2 regulation of Toll-like receptor responses and the pathogenesis of Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Signalling pathways and molecular interactions of NOD1 and NOD2

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3)

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genetic markers may predict disease behavior in patients with ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Clinical and genetic heterogeneity in Mexican patients with ulcerative colitis.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

A population- and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The incidence of ulcerative colitis in Northern Norway from 1983 to 1986. The Northern Norwegian Gastroenterology Society.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The contribution of human leucocyte antigen complex genes to disease phenotype in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Further evidence of IBD5/CARD15 (NOD2) epistasis in the susceptibility to ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Islands of linkage disequilibrium

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The Contribution of OCTN1/2 Variants Within the IBD5 Locus to Disease Susceptibility and Severity in Crohn’s Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Functional variants of OCTN cation transporter genes are associated with Crohn disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

High-resolution haplotype structure in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association of Organic Cation Transporter Risk Haplotype With Perianal Penetrating Crohn’s Disease but Not With Susceptibility to IBD

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Colonic epithelial functional phenotype varies with type and phase of experimental colitis.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Altered expression and function of P-glycoprotein in dextran sodium sulfate-induced colitis in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent Northern European populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

MDR1 gene polymorphism in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

MDR1 Ala893 polymorphism is associated with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genetic variation in DLG5 is associated with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Clustering of increased small intestinal permeability in families with Crohn's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association of DLG5 R30Q variant with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

DLG5 variants contribute to Crohn disease risk in a Canadian population

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The promise and perils of interpreting genetic associations in Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Recognition of microbial infection by Toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: phenotype-genotype correlations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association between Toll-like receptor 4 and inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The bacterial flagellin gene as a biomarker for detection, population genetics and epidemiological analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

CARD4/NOD1 is not involved in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

NOD1 variation, immunoglobulin E and asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Synergistic enhancement of Toll-like receptor responses by NOD1 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

The IBD International Genetics Consortium Provides Further Evidence for Linkage to IBD4 and Shows Gene-Environment Interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Understanding Association and Causality in the Genetic Studies of Inflammatory Bowel Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

Association of DLG5 and inflammatory bowel disease across populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2968345-1

7 January 2021

10.1016/S0140-6736(06)68345-1

Identifiers

DOI

1 reference

release_kcyonicxyfe5xog3kimxvkdugy

14 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kcyonicxyfe5xog3kimxvkdugy

24 November 2022

mapped directly with Wikidata item

1 reference