Screening reactive metabolites bioactivated by multiple enzyme pathways using a multiplexed microfluidic system (Q36431430)

14 August 2017

Screening reactive metabolites bioactivated by multiple enzyme pathways using a multiplexed microfluidic system (English)

1 reference

14 August 2017

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Amit A Joshi

4

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Dhanuka P Wasalathanthri

object named as

Dhanuka P Wasalathanthri

1

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Ronaldo C Faria

object named as

Ronaldo C Faria

2

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author name string

Spundana Malla

3

1 reference

14 August 2017

John B Schenkman

5

1 reference

14 August 2017

James F Rusling

6

1 reference

14 August 2017

25 October 2012

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14 August 2017

1 reference

14 August 2017

138

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14 August 2017

1

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14 August 2017

171-178

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describes a project that uses

14 August 2017

1 reference

Microfluidic electrochemical array for detection of reactive metabolites formed by cytochrome P450 enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Bioelectronic delivery of electrons to cytochrome P450 enzymes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Managing the challenge of chemically reactive metabolites in drug development.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Evaluation of electrochemiluminescent metabolic toxicity screening arrays using a multiple compound set.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Efficient bioelectronic actuation of the natural catalytic pathway of human metabolic cytochrome P450s.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

High-throughput metabolic toxicity screening using magnetic biocolloid reactors and LC-MS/MS.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

How to improve R&D productivity: the pharmaceutical industry's grand challenge

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Rapid LC-MS drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Differences in metabolite-mediated toxicity of tamoxifen in rodents versus humans elucidated with DNA/microsome electro-optical arrays and nanoreactors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Biochemical applications of ultrathin films of enzymes, polyions and DNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Thin film voltammetry of metabolic enzymes in rat liver microsomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Electrochemiluminescent/voltammetric toxicity screening sensor using enzyme-generated DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Toxicity screening using biosensors that measure DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

The origins and the future of microfluidics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Some distinctions between flavin-containing and cytochrome P450 monooxygenases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Cytochrome P450 activation of arylamines and heterocyclic amines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Improving the decision-making process in structural modification of drug candidates: reducing toxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Sensors for toxicity of chemicals and oxidative stress based on electrochemical catalytic DNA oxidation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Epoxide hydrolases: biochemistry and molecular biology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

The TD50: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Measurement of protein using bicinchoninic acid

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3509269

Nonlocal transport in the quantum spin Hall state

30 September 2017

1 reference

https://api.crossref.org/works/10.1039%2FC2AN35993F

Quantitative measurement of DNA adducts using neutral hydrolysis and LC-MS. Validation of genotoxicity sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2AN35993F

Detection of chemically induced DNA damage in layered films by catalytic square wave voltammetry using Ru(bpy)3(2+).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2AN35993F

Toxicity screening by electrochemical detection of DNA damage by metabolites generated in situ in ultrathin DNA-enzyme films

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2AN35993F

Enzyme-DNA biocolloids for DNA adduct and reactive metabolite detection by chromatography-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2AN35993F

Simultaneous direct electrochemiluminescence and catalytic voltammetry detection of DNA in ultrathin films.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2AN35993F

Protein film electrochemistry of microsomes genetically enriched in human cytochrome p450 monooxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2AN35993F

Electrochemical genotoxicity screening for arylamines bioactivated by N-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2AN35993F

Purification, physicochemical, and kinetic properties of liver acetyl-CoA:arylamine N-acetyltransferase from rapid acetylator rabbits

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23095952

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23095952

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23095952

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1039/C2AN35993F

1 reference

14 August 2017

1 reference

14 August 2017

1 reference